AEEA-AEEA

I-AEEA-AEEA (i-Aminoethoxyethoxyacetate dimer)

Isicelo soPhando:
I-AEEA-AEEA yi-hydrophilic, i-flexible spacer edla ngokusetyenziswa kwi-peptide kunye nophando lokudibanisa iziyobisi. Iqukethe iiyunithi ezimbini ezisekelwe kwi-ethylene glycol, okwenza kube luncedo ekufundeni imiphumo ye-linker ubude kunye nokuguquguquka kwintsebenziswano ye-molecular, i-solubility, kunye nomsebenzi we-biological. Abaphandi bahlala besebenzisa iiyunithi ze-AEEA ukuvavanya ukuba i-spacers zinefuthe njani ekusebenzeni kwe-antibody-drug conjugates (ADCs), i-peptide-drug conjugates, kunye nezinye i-bioconjugates.

Umsebenzi:
I-AEEA-AEEA isebenza njenge-biocompatible linker ephucula ukunyibilika, ukunciphisa umqobo we-steric, kunye nokuphucula ukuguquguquka kwe-molecular. Inceda ukwahlula imimandla esebenzayo ngaphakathi kwemolekyuli, njengokujolisa kwi-ligands kunye ne-payloads, okuvumela ukubopha okusebenzayo kunye nomsebenzi. Ubume bayo obungeyona i-immunogenic kunye ne-hydrophilic nayo inegalelo ekuphuculweni kweeprofayili ze-pharmacokinetic kwizicelo zonyango.