Fmoc-Thr(tBu)-Phe-OH

Fmoc-Thr(tBu)-Phe-OH

Isicelo soPhando:
I-Fmoc-Thr(tBu)-Phe-OH yibhloko yokwakha yeedipeptide eqhele ukusetyenziswa kwi-soli-phase peptide synthesis (SPPS). Iqela le-Fmoc (i-9-fluorenylmethyloxycarbonyl) likhusela i-N-terminus, ngelixa iqela le-tBu (tert-butyl) likhusela i-hydroxyl side chain of threonine. Le dipeptide ikhuselweyo iphononongwa ngendima yayo ekuququzeleleni ulwalulo olululo lwepeptide, ukunciphisa iracemization, kunye nokwenza imodeli yemotifs yolandelelwano oluthile kulwakhiwo lweprotheyini kunye nezifundo zokusebenzisana.

Umsebenzi:
I-Fmoc-Thr (tBu) -Phe-OH isebenza njenge-precursor yokudibanisa i-peptides equka i-threonine kunye neentsalela ze-phenylalanine, ezibalulekileyo ekwenzeni iibhondi ze-hydrogen kunye nokusebenzisana kwe-hydrophobic. Itsheyini elisecaleni lethreonine linegalelo kwipolarity kunye neziza ezinokubakho zephosphorylation, ngelixa i-phenylalanine yongeza uphawu olunevumba elimnandi kunye nokuzinza kwesakhiwo. Le ndibaniselwano iluncedo ekuyileni iipeptides zovavanyo lwebhayoloji, izifundo zokubopha i-receptor, kunye nezicelo zokufunyanwa kweziyobisi.