IGlepaglutide

Glepaglutide API

I-Glepaglutide yi-analog ye-GLP-2 yexesha elide eyenzelwe unyango lwe-bowel syndrome (SBS). Yandisa ukufunxwa kwamathumbu kunye nokukhula, inceda izigulane ukunciphisa ukuxhomekeka kwisondlo sabazali.

Inkqubo kunye noPhando:

I-Glepaglutide ibophelela kwi-glucagon-like peptide-2 receptor (GLP-2R) emathunjini, ikhuthaza:
Ukukhula kwe-Mucosal kunye nokuvuselelwa
Ukuphuculwa kokufunxa izondlo kunye nolwelo
Ukunciphisa ukuvuvukala kwamathumbu

Izifundo zeklinikhi zibonise ukuba iGlepaglutide inokunyusa ukusebenza kwamathumbu kunye nokuphucula umgangatho wobomi kwizigulana ze-SBS.

Iimpawu ze-API (iQela leGentolex):

I-analog ye-peptide esebenza ixesha elide
Iveliswe nge-soli-phase peptide synthesis (SPPS)
Ukucoceka okuphezulu (≥99%), umgangatho onjenge-GMP

I-Glepaglutide API lunyango oluthembisayo lokungaphumeleli kwamathumbu kunye nokuvuselelwa kwamathumbu.