I-GLP-1 Ekhuselweyo ye-Amino Acid yoLungiso lweSixokelelwano esisecaleni
Iinkcukacha zeMveliso
| HAYI. | Iimveliso | Inombolo yeCAS. | Isicelo | Isalathisi soMgangatho oPhambili | ||||
| Ubunyulu | Isomer | SI * | Ubukhulu * | Ukufuma | ||||
| 1 | Fmoc-Lys(Mtt)-OH | 167393-62-6 | Lysine side ukuguqulwa chain | ≥99.0% | ≤0.1% | ≤0.2% | ≤0.3% | ≤1.0% |
| 2 | Fmoc-Lys(Alloc)-OH | 146982-27-6 | Lysine side ukuguqulwa chain | ≥99.5% | ≤0.1% | ≤0.1% | ≤0.2% | ≤1.0% |
| 3 | Fmoc-Lys(ivDde)-OH | 150629-67-7 | Lysine side ukuguqulwa chain | ≥98.0% | ≤0.2% | ≤0.3% | ≤0.5% | ≤1.0% |
| 4 | Fmoc-Lys(Mmt)-OH | 159857-60-0 | Lysine side ukuguqulwa chain | ≥98.0% | ≤0.2% | ≤0.3% | ≤0.5% | ≤1.0% |
| 5 | Fmoc-Glu-OtBu | 84793-07-7 | ILiraglutideSemaglutide | ≥99.5% | ≤0.1% | ≤0.1% | ≤0.2% | ≤1.0% |
| 6 | Glu-OtBu | 45120-30-7 | ILiraglutideSemaglutide | ≥99.5% | ≤0.1% | ≤0.1% | ≤0.2% | ≤1.0% |
| 7 | Octadecanedioic acid | 871-70-5 | Semaglutide | ≥99.0% | / | ≤0.2% | ≤0.3% | ≤1.0% |
| 8 | Octadecanedioic acid mono-tert-butyl ester | 843666-40-0 | Semaglutide | ≥99.0% | / | ≤0.2% | ≤0.3% | ≤1.0% |
| 9 | tBu-OOC-C16-CO-Glu-OtBu | 1188328-39-3 | SemaglutideIqhekeza A | ≥98.0% | ≤0.2% | ≤0.5% | ≤0.5% | ≤1.0% |
| 10 | EEEA | 134978-97-5 | SemaglutideAlbuvirtide | ≥99.0% | / | ≤0.2% | ≤0.3% | ≤1.0% |
| 11 | AEEA-OH.HCl | 134979-01-4 | SemaglutideAlbuvirtide | ≥99.0% | / | ≤0.2% | ≤0.3% | ≤1.0% |
| 12 | Fmoc-AEEA-OH | 166108-71-0 | SemaglutideAlbuvirtide | ≥99.0% | / | ≤0.2% | ≤0.3% | ≤1.0% |
| 13 | Boc-AEEA-OH | 108466-89-3 | Semaglutide | ≥99.0% | / | ≤0.2% | ≤0.3% | ≤1.0% |
| 14 | AEEA-AEEA | 1143516-05-5 | Semaglutide | ≥98.0% | ≤0.2% | ≤0.5% | ≤0.5% | ≤1.0% |
| 15 | Fmoc-AEEA-AEEA-OH | 560088-89-3 | SemaglutideIqhekeza B | ≥98.0% | ≤0.2% | ≤0.5% | ≤0.5% | ≤1.0% |
| 16 | Octa(OtBu)-Glu(ɑ-OtBu)-AEEA-AEEA-OH | 1118767-16-0 | SemaglutideIqhekeza C | ≥98.0% | ≤0.2% | ≤0.5% | ≤0.5% | ≤1.0% |
| 17 | I-tBu-OOC-C16-CO-Glu(AEEA-AEEA-NHS)-OtBu | 1118767-15-9 | SemaglutideIqhekeza D | ≥96.0% | ≤0.5% | ≤1.0% | ≤1.0% | ≤1.0% |
| 18 | I-Fmoc-Ls(tBu-OOC-C16-CO-Glu(AEEA-AEEA)-OtBu)-OH | 1662688-20-1 | Iqhekeza leSemaglutide E | ≥96.0% | ≤0.5% | ≤1.0% | ≤1.0% | ≤1.0% |
| 19 | Boc-Wakhe(Trt)-OH | 32926-43-5 | Isiphelo yi-histidine | ≥99.5% | ≤0.1% | ≤0.1% | ≤0.2% | ≤4.0% |
| 20 | Fmoc-Aib-OH | 94744-50-0 | Semaglutide | ≥99.5% | / | ≤0.1% | ≤0.2% | ≤1.0% |
| 21 | Boc-Wakhe(Trt)-Aib-OH | 2061897-68-3 | Semaglutide | ≥99.0% | ≤0.1% | ≤0.2% | ≤0.3% | ≤2.0% |
| 22 | I-Fmoc-Glu(OtBu)-Gly-OH | 866044-63-5 | I-analogue ye-GLP-1 | ≥99.5% | ≤0.1% | ≤0.2% | ≤0.2% | ≤1.0% |
| 23 | Boc-His(Trt)-Aib-Glu(OtBu)-Gly-OH | 1169630-31-2? | Semaglutide Fragment F | ≥98.0% | ≤0.2% | ≤0.5% | ≤0.5% | ≤1.0% |
| 24 | Boc-His(Trt)-Aib-Glu(OtBu)-Gly-NHS | 1169630-40-3 | Iqhekeza leSemaglutide G | ≥96.0% | ≤0.5% | ≤1.0% | ≤1.0% | ≤1.0% |
| 25 | I-Fmoc-Arg(pbf)-Gly-OH | 660846-80-0 | I-analogue ye-GLP-1 | ≥99.5% | ≤0.1% | ≤0.2% | ≤0.2% | ≤1.0% |
| 26 | Fmoc-Ala-Ala-OH | 87512-31-0 | I-analogue ye-GLP-1 | ≥99.5% | ≤0.1% | ≤0.2% | ≤0.2% | ≤1.0% |
| 27 | Fmoc-Thr(tBu)-Phe-OH | 1260609-75-3 ? | I-analogue ye-GLP-1 | ≥99.5% | ≤0.1% | ≤0.2% | ≤0.2% | ≤1.0% |
| 28 | Palmitic acid | 1957/10/3 | Iqhekeza leLiraglutide 1 | ≥99.0% | / | ≤0.2% | ≤0.3% | ≤1.0% |
| 29 | Palm-Glu-OtBu | NA | Iqhekeza le-Liraglutide 2 | ≥98.0% | ≤0.2% | ≤0.5% | ≤0.5% | ≤1.0% |
| 30 | Palm-Glu(NES)-OtBu | NA | Iqhekeza le-Liraglutide 3 | ≥96.0% | ≤0.5% | ≤1.0% | ≤1.0% | ≤1.0% |
| 31 | I-Fmoc-Ls(Palm-Glu-OtBu)-OH | 1491158-62-3 | ILiraglutide | ≥98.0% | ≤0.2% | ≤0.5% | ≤0.5% | ≤1.0% |
| 32 | Hexadecanedioic acid | 505-54-4 | I-insulin degludec | ≥99.0% | / | ≤0.2% | ≤0.3% | ≤1.0% |
| 33 | Hexadecanedioic acid mono-tert-butyl ester | 843666-27-3 | I-insulin degludec | ≥99.0% | / | ≤0.2% | ≤0.3% | ≤1.0% |
| 34 | tBu-OOC-C14-CO-Glu-OtBu | NA | I-insulin degludec Fragment I | ≥98.0% | ≤0.2% | ≤0.5% | ≤0.5% | ≤1.0% |
| 35 | I-tBu-OOC-C14-CO-Glu(NES)-OtBu | NA | I-insulin degludec Fragment II | ≥96.0% | ≤0.5% | ≤1.0% | ≤1.0% | ≤1.0% |
SI *= Ukungcola Okukodwa
Ubukhulu*= Ubuninzi bokungacoceki okungaziwayo
Esinye isalathisi:
-Acetic Acid: ≤0.02% (Zonke iimveliso)
-Ethyl Acetate: ≤0.5% (Zonke Iimveliso)
- Utywala: ≤0.5% (Zonke Iimveliso)
Ucoceko
Ucoceko lwenkqubo yokuhambisa, kubandakanywa iluphu kunye netanki yokugcina kwenziwa yiPasteurization. Xa kwenziwa i-Pasteurization sanitization, amanzi acociweyo kwitanki afudunyezwa ukuya kuthi ga kwi-80 ° C kwaye aqalise ukujikeleza ngenkqubo yokuhambisa. Ucoceko luthatha iyure enye emva kokufikelela kuma-80°C. Ucoceko lwenziwa rhoqo ngekota. Incwadi yelog yenkqubo yamanzi acociweyo yococeko iye yajongwa kungekho luhambo lubonakalisiweyo.
