I-GNRH AMANQAKU esetyenziselwa i-Poptides Synthesis
Iinkcukacha zemveliso
| NO | Iimveliso | I-CASS No. | Isicelo | Isalathiso seXabiso eliPhambili | ||||
| Ubunyulu | Isomer | Ukungalungisi | * UMax1 | Ukufuma | ||||
| 1 | I-FMOC-3- (2-naphthyl) -D-AO-OH | 138774-94-4 | Uninzi lweemveliso | ≥99.0% | ≤0.2% | ≤0.3% | ≤0.3% | ≤1.0% |
| 2 | I-AC-3- (2-naphthyl) -D-AO-OH | 37440-01-0-0 | Uninzi lweemveliso | ≥99.0% | ≤0.2% | ≤0.3% | ≤0.3% | ≤1.0% |
| 3 | I-FMOC-3- (3-pyridlinyl) -D-AO-OH | I-142994-44-4 | Uninzi lweemveliso | ≥99.0% | ≤0.2% | ≤0.3% | ≤0.3% | ≤1.0% |
| 4 | I-FMOC-4-CHLO-D-DHE-OH | I-142994-19-2 | Uninzi lweemveliso | ≥99.0% | ≤0.2% | ≤0.3% | ≤0.3% | ≤1.0% |
| 5 | I-FMOC-D-Q-GAR-OH | Ngo-20034433-8-8 | I-cetrorelix | ≥99.5% | ≤0.1% | ≤0.1% | ≤0.2% | ≤1.0% |
| 6 | I-FMOC-D-ALA-OH.H2O | I-79990-15-15-1 | Uninzi lweemveliso | ≥99.5% | ≤0.1% | ≤0.1% | ≤0.2% | ≤6.5% |
| 7 | I-FMOC-D-APH (TBUCBM) -oh | 1433975-21-3 | I-tigarealix | ≥99.0% | ≤0.2% | ≤0.3% | ≤0.3% | ≤1.0% |
| 8 | I-FMOC-D-APH (CBM) -OOh | 324017-22-33 | I-tigarealix | ≥99.0% | ≤0.2% | ≤0.3% | ≤0.3% | ≤1.0% |
| 9 | I-Fmoc-L-APH (L-HOR) -OOH | 1253282-31-31-3 | I-tigarealix | ≥99.0% | ≤0.2% | ≤0.3% | ≤0.3% | ≤1.0% |
| 10 | I-FMOC-L-LYS (iPRE, BOC) -OOH | Ngo-201003-48-7-7-7-7 | I-tigarealix | ≥99.0% | ≤0.2% | ≤0.3% | ≤0.3% | ≤1.0% |
| 11 | I-Fmoc-n-ty-tyr (tbu) -oh | 13337-4-7 | I-barelix | ≥99.0% | ≤0.2% | ≤0.3% | ≤0.3% | ≤1.0% |
| 12 | I-FMOC-D-ASN ASN (TRT) -OOH | I-180570-71-2 | I-barelix | ≥99.0% | ≤0.2% | ≤0.3% | ≤0.3% | ≤1.0% |
| 13 | I-Fmoc-homoarg (et) 2-oh.hcl | I-1864003-26-8 | Ganirelix | ≥95.0% | ≤0.5% | ≤1.0% | ≤2.0% | ≤2.0% |
| 14 | I-Fmoc-D-homoarg (et) 2-oh.hcl | 2098497-24-4 | Ganirelix | ≥95.0% | ≤0.5% | ≤1.0% | ≤2.0% | ≤2.0% |
| 15 | I-Fmoc-lys (iNicotinoyl) -oh | I-25204-11-9-9-9 | I-antide | ≥98.0% | ≤0.2% | ≤0.3% | ≤0.5% | ≤1.0% |
| 16 | I-FMOC-D LYS (NICOITOYL) -OOH | I-25204-12-0 | I-antide | ≥98.0% | ≤0.2% | ≤0.3% | ≤0.5% | ≤1.0% |
* UMax1 = i-max engaziwayo engaziwayo
Olunye uphawu:
-I-acetic acid: ≤0.02% (zonke iimveliso)
- I-Ethyl Acetate: ≤0.5% (Zonke iimveliso)
-Utywala: ≤0.5% (zonke iimveliso)
I-TOC kunye neKhuphiswano
I-TOC kunye nokuqhubela phambili koncedo oluphambili kunye nokubuyiswa kubekwe esweni amaxesha ngamaxesha. I-TOC ijongwa yi-QC ngeveki nganye. Ukuyekiswa kubekwe esweni kwi-intanethi kwaye kurekhodwa ngumqhubi wesikhululo samanzi acocekileyo kube kanye kwiiyure ezine. Ukuqhubela phambili kubekwe esweni kwiPrayimari yasePro, Sekondari Ro, uEdi kunye nendawo ebuyisiweyo yenkqubo yokuhambisa. Ukucaciswa kwamanzi acocekileyo kusendaweni kwaye kuyahambelana nenkcazo echazwe kwangaphambili engaphantsi kwe-1.3 s / cm nge-25 ° C (i-US (i-USP). Ukubonelela okuphambili kunye namanqaku okubuya, uvavanyo olupheleleyo. iqhutywa veki nganye, yomnye inqaku elisebenzisa inqaku lokujikeleza i-loop, uvavanyo olupheleleyo lwenziwa kanye ngenyanga. Oluvavanyo olupheleleyo lubandakanya abalinganiswa, i-PH, i-nitrate, nitrite, i-Amonia, i-TOC, i-TOC, imida ye-rotional, imida yentsholongwane kunye ne-upotoxring.
