I-Inclisiran sodium

Inclisiran Sodium (API)

Isicelo soPhando:
I-Inclisiran sodium API (i-Active Pharmaceutical Ingredient) ifundwa ngokuyinhloko kwintsimi ye-RNA interference (RNAi) kunye ne-cardiovascular therapeutics. Njenge-siRNA ephindwe kabini ejolise kwi-PCSK9 gene, isetyenziselwa uphando lwangaphambili kunye nophando lweklinikhi ukuvavanya izicwangciso zexesha elide zokuthulisa imfuza yokunciphisa i-LDL-C (i-low-density lipoprotein cholesterol). Ikwasebenza njengekhompawundi yemodeli yokuphanda ngeenkqubo zokuhanjiswa kwe-siRNA, uzinzo, kunye nonyango lwe-RNA olujoliswe esibindini.

Umsebenzi:
I-Inclisiran sodium API isebenza ngokuthulisa i-PCSK9 gene kwi-hepatocytes, ekhokelela ekunciphiseni ukuveliswa kweprotheyini ye-PCSK9. Oku kuphumela ekuphuculweni kokuphinda kusetyenziswe ii-receptors ze-LDL kunye nokukhutshwa okukhulu kwe-cholesterol ye-LDL egazini. Umsebenzi wayo njenge-agent yexesha elide yokunciphisa i-cholesterol isekela ukusetyenziswa kwayo ekuphatheni i-hypercholesterolemia kunye nokunciphisa umngcipheko wesifo senhliziyo. Njenge-API, yenza i-core component esebenzayo kwi-Inclisiran-based based formulations.