I-Leuprorelin Acetate ilawula iSecretion of Gonadal Hormones
Iinkcukacha zeMveliso
| Igama | Leuprorelin |
| Inombolo yeCAS | 53714-56-0 |
| Ifomula yemolekyuli | I-C59H84N16O12 |
| Ubunzima bemolekyuli | 1209.4 |
| Inombolo ye-EINECS | 633-395-9 |
| Ukujikeleza okuthe ngqo | I-D25 -31.7 ° (c = 1 kwi-1% i-acetic acid) |
| Ukuxinana | 1.44±0.1 g/cm3(Kuxelwe kwangaphambili) |
| Imeko yokugcina | -15°C |
| Ifom | Icocekile |
| I-acidity coefficient | (pKa) 9.82±0.15 (Kuxelwe kwangaphambili) |
| Ukunyibilika kwamanzi | I-Soluble emanzini kwi-1mg / ml |
Izithethantonye
LH-RHLEUPROLIDE;LEUPROLIDE;LEUPROLIDE(HUMAN);LEUPRORELIN;[DES-GLY10,D-LEU6,PRO-NHET9]-LUTEINIZINGHORMONE-RELEASINGHORMONEHUMAN;(DES-GLY10,D-LEU6,PRO -NHET9)-LUTEINIZINGHORMONE-RELEASINGHORMONE;(DES-GLY10,D-LEU6,PRO-NHET9)-LUTEINIZINGHORMONE-REASINGFACTOR;[DES-GLY10,D-LEU6,PRO-NHET9]-LH-RH(UMNTU)
Isiphumo se-Pharmacological
I-Leuprolide, i-goserelin, i-triprelin, kunye ne-nafarelin ngamachiza amaninzi aqhelekileyo asetyenziswa kwiklinikhi yokususa ii-ovari kunyango lomhlaza webele we-premenopausal kunye nomhlaza we-prostate. (ekubhekiselwa kuyo njengeziyobisi ze-GnRH-a), amachiza e-GnRH-a ayafana ngesakhiwo kwi-GnRH kwaye akhuphisana ne-pituitary GnRH receptors. Oko kukuthi, i-gonadotropin efihliweyo yi-pituitary iyancipha, ekhokelela ekunciphiseni okukhulu kwehomoni yesini efihliweyo yi-ovary.
I-Leuprolide yi-gonadotropin-releasing hormone (GnRH) analog, i-peptide eyenziwe nge-9 amino acids. Le mveliso inokuthintela ngokufanelekileyo umsebenzi wenkqubo ye-pituitary-gonadal, ukuchasana ne-proteolytic enzymes kunye nokuxhamla kwi-pituitary GnRH receptor yomelele kune-GnRH, kwaye umsebenzi wokukhuthaza ukukhululwa kwe-hormone ye-luteinizing (LH) malunga namaxesha angama-20 kwi-GnRH. Ikwanayo nefuthe elinamandla lokuthintela ukusebenza kwe-pituitary-gonad kune-GnRH. Kwinqanaba lokuqala lokonyango, i-follicle stimulating hormone (FSH), i-LH, i-estrogen okanye i-androgen inokunyuswa okwethutyana, kwaye ke, ngenxa yokuncipha kokuphendula kwe-pituitary gland, ukukhutshwa kwe-FSH, i-LH kunye ne-estrogen okanye i-androgen ivinjelwe, okubangelwa ukuxhomekeka kwi-hormone yesini. Izifo zesondo (ezifana nomhlaza wesifo seprotate, i-endometriosis, njl.) zinefuthe lonyango.
Okwangoku, ityuwa ye-acetate ye-leuprolide isetyenziswa kakhulu kwikliniki, kuba ukusebenza kwe-acetate ye-leuprolide kuzinzile kwiqondo lokushisa. Ulwelo kufuneka ilahlwe. Ingasetyenziselwa unyango lokuthenwa kweyeza le-endometriosis kunye ne-uterine fibroids, ukufikisa okusembindini, umhlaza wamabele we-premenopausal kunye nomhlaza wesibeleko, kunye nokopha kwe-uterine esebenzayo echaseneyo okanye engasebenziyo kunyango lwe-hormone eqhelekileyo. Inokusetyenziswa kwakhona njenge-premedication phambi kwe-endometrial resection, enokunciphisa ngokulinganayo i-endometrium, ukunciphisa i-edema, kunye nokunciphisa ubunzima botyando.
