I-Liraglutide Anti-Diabethers kwi-CASSIN YOLWAZI LWE-CASSINO LO.204656-20-20-20-2 Inemifanekiso

I-Liraglutide Anti-Diabethers kwi-Cas yoLawulo lweswekile yeGazi leSuby No.204656-20-20-2

Inkcazo emfutshane:

Isithako esisebenzayo:I-Liraglutide (i-analog ye-Glucagon-enje-i-peptde-1 (i-GLP-1) iveliswe yigwele ngeteknoloji yokubuyela kwimeko yesilivere).

Igama leekhemikhali:I-Arg34lys26- (N-ε- (γ-glu (n-α-hexadecanoyl))))) - I-GLP-1 [7-37]

Ezinye izithako:I-Shromogesium hydrogen phosphate dishylow, i-propylene glycol, hydrocloric acid kunye / okanye i-sodium hydroxide (kunye ne-phenolters) kuphela), kunye nenaliti.

Thumela i-imeyile kuthi

Iinkcukacha zemveliso

Iimpawu zeMveliso

Iinkcukacha zemveliso

I-CAS	204656-20-20-2	Ifomula yemolekyula	C₁₇₂H₂₆₅N₄₃O_I-51
Ubunzima bemolekyuli	3751.20	Imbonakalo	Mhlophe
Imeko yokugcina	Ukuxhathisa ukukhanya, i-2-8 degree	Iphakheji	I-Alumuminium ye-Aluminium ye-villa / i-vial
Ubunyulu	≥98%	Ukuthutha	I-chain ebandayo kunye nokuhanjiswa okupholileyo

Izithako zeLiraglutide

Isithako esisebenzayo:

I-Liraglutide (i-analog ye-Glucagon-enje-i-peptde-1 (i-GLP-1) iveliswe yigwele ngeteknoloji yokubuyela kwimeko yesilivere).

Igama leekhemikhali:

I-Arg34lys26- (N-ε- (γ-glu (n-α-hexadecanoyl))))) - I-GLP-1 [7-37]

Ezinye izithako:

I-Shromogesium hydrogen phosphate dishylow, i-propylene glycol, hydrocloric acid kunye / okanye i-sodium hydroxide (kunye ne-phenolters) kuphela), kunye nenaliti.

Isicelo

Chwetheza isifo seswekile

I-Liraglutide iphucula ulawulo lweglucose yegazi. Inciphisa i-hyperglycemia enxulumene nesidlo (iiyure ezingama-24 emva kolawulo) ngokukhula kwe-insulin kwi-insulin (kuphela) xa ifuneka ngokwanda kwe-glucose ye-Glucagon.
Ilungele izigulana ezifakelwa iswekile yegazi isesingahlawulelwa kakubi emva kwedosi enesidima esinengxaki ye-metfonylin okanye i-Sulfonylias yodwa. Isetyenziselwa ukudityaniswa kunye ne-metfontin okanye i-Sulfonylires.
Isebenza ngendlela enokuxhomekeka eglucose, okuthetha ukuba iya kukukhuthaza i-Insulin kuphela xa amanqanaba egazi amagazi aphezulu kunesiqhelo, ukuthintela "I-Overshoot". Ngenxa yoko, ibonisa umngcipheko ongaqondakaliyo we-hypoglycemia.
Inokubakho kwi-Apoptosis kunye nokukhuthaza ukuvuselelwa kwakhona kweeseli ze-beta (ezibonwe kwizifundo zezilwanyana).
Iyancipha ngokutya kwaye ithintele inzuzo yobunzima bomzimba, njengoko kubonisiwe kwisifundo sentloko-to-to-to-velogureside.

Inketho ye-Pharmacological

I-Liraglutide yi-anag-1 i-anag nge-97% yokulandelelana kwe-chmology kwi-GLP yabantu i-GLP-1, enokubopha kwaye isebenze kwi-GLP-1 Remptor. I-GLP-1 i-GLP-1 ye-GLP yithagethi ye-GLP-1, i-Endogenous e-Endogetin yeHormone ekhuthaza ubuchule be-glucose ye-isulin. Ngokungafaniyonyani i-GLP-1, i-pharmaconkinic kunye ne-pharmacodynamic kunye ne-pharmacodynamic ye-liraglutide ebantwini zilungele irejimeni ye-dong. Emva kwenaliti engacocekanga, indlela yayo yesenzo ixesha elide ibandakanya: ukuzithoba okucothisayo; Ukubopha kwi-albhamun; Uzinzo oluphezulu lwe-enzyme kwaye ke kwaneplasma ende-nye.

Umsebenzi we-liraglutide udityaniswe ngunxibelelwano oluthile kunye ne-receptor ye-GLP-1, kukhokelela kwinyoka kwe-cyclic adenosine monophosphate (inkampu). I-Liraglutide ivuselela imbonakalo ye-insulin ngendlela enokuchaphazeleka, ngelixa inciphisa ukhuseleko lwe-glucagon kwindawo exhomekeke kwi-glucose.

Ke ngoko, xa i-Glucose yegazi iphakama, ukufihlakala kwe-insulin kuyashukunyiswa, ngelixa i-Glucaguagon ithintelwe. Ngokwahlukileyo, i-liraglutide inciphisa ukufihlakala kwi-infpoglycemia ngaphandle kokuchaphazela i-glucagon. Indlela ye-hypoglycemicy ye-liraglutide ikwabandakanya ukwenziwa kwexesha elincinci lexesha lokukhupha ixesha eliphakamileyo. I-Liraglutide inciphisa ubunzima bomzimba kunye nobunzima bomzimba ngokunciphisa indlala kunye namandla athabathiweyo.

Ngaphambili: UMFAZI WAMABHUNGA OLUFAZIYO-I-TRIATATATE API ye-OSTOOPOPOPOPOOPOOPOOPOUROUROUROUROUROUROUROUROOFOOS I-US.5223-67 - I-Gentolex

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