Imelanotan 1

Melanotan 1 API

Imelanotan 1yi peptide yokwenziwa analog yeI-α-MSH (ihomoni evuselela i-alpha-melanocyte). Isebenza ngeukwenza i-melanocortin-1 receptors (MC1R)ukuvuselelaukuveliswa kwe-melanin, ukunikela ngokwendaloulusu lwebalakwayeukhuseleko lwefoto.

Ibeyiivunyiwe kunyango lwe-erythropoietic protoporphyria (EPP)-Ingxaki engaqhelekanga ebangela ukuba novakalelo olugqithisileyo ekukhanyeni kwelanga. I-Melanotan 1 inceda ukwandaukunyamezela ukukhanya kwe-UV, nciphisaukusabela phototoxic, kwaye uphuculeukukhusela ulusu kumonakalo owenziwe yi-UV.

Indlela yokwenza

• KhethaMC1R iagonist

• Ukonyukaukuveliswa kwe-eumelanin

• Uyabonelelaukukhuselwa kwelanga lendalo

• IxhasaUkulungiswa kweDNA kunye nempendulo echasayo

Usetyenziso

• Enokwenzeka kwii-vitiligo, ukuthintela umhlaza wolusu, kwayei-pigmentation yokuthambisa

• Kujongwe ngaphakathianti-ukugugakwayeunyango lwedermatological

Iimpawu ze-API (iQela leGentolex)

• Ukucoceka okuphezulu ≥99%

• I-Solid-phase peptide synthesis (SPPS)

• Imigangatho yokuvelisa efana ne-GMP

• Ubonelelo olunokwehla: I-R&D ukuya kumanqanaba orhwebo