Melanotan II

Melanotan II API

Melanotan IIyi-synthetic cyclic heptapeptide analog yeihomoni evuselela i-α-melanocyte (α-MSH), iphuhliswe ukuyaivuselela i-melanogenesis, phuculaUkukhuselwa kwe-UV, kwaye uhlengahlengiseimisebenzi ngokwesondo kunye metabolic. Isebenza njengei-agonist engakhethiyoi-melanocortin receptors, ngakumbiI-MC1R, MC3R, kwayeI-MC4R.

Ekuqaleni wafundela kuyoukusukwakwayephotoprotectiveiipropati, i-Melanotan II nayo ibonise iziphumo kwiukuphucula i-libido, ukucinezelwa kokutya, kwayeibhalansi yamandla, okwenza ukuba ibe yi-peptide yophando olusebenzayo kunye nomdla kwi-dermatology, i-endocrinology, kunye neyeza zesondo.

Indlela yokwenza

I-Melanotan II isebenza ngokuvula ii-receptors ezininzi ze-melanocortin:

• I-MC1R: Iyavuselelaukuveliswa kwe-melanin→ kwandisa umbala wolusu kunye nokhuseleko lwe-UV

• MC3R/MC4R: Ingene kwiulawulo lokutya, ukuphucula i-libido, kwayei-homeostasis yamandla

• Unqumla umqobo wegazi-ubuchopho, ukuphembelela iindlela ezingundoqo ze-neurohormonal

Uphando kunye nezicelo ezinokuthi zibe kho

Nangona ingavunywanga ukusetyenziswa kwezonyango, iMelanotan II ifundwe ngokubanzi kwezi zilandelayo:

1. I-Skin Pigmentation kunye noKhuseleko lwe-UV

• Iyanyusaeumelanin synthesis, ikhokhelela kwiukusukwa kwendalo

• Uyabonelelaiziphumo zokukhusela iifotongaphandle kokutshiswa lilanga

• Okunokwenzeka ekunciphiseni umngcipheko womhlaza wolusu kubantu abanolusu olulungileyo

2. Ukungasebenzi kakuhle ngokwesondo

• Iboniswe kwiukwandisa i-libido kunye nokuvuselela ngokwesondoemadodeni nakwabafazi

• Ufundelwe njengonyango olunokwenzekaukungasebenzi kakuhle kwe-erectile (ED)ngokusebenzisa i-MC4R isebenze

3. Umdla kunye noLawulo lobunzima

• UCanzibeukunciphisa ukutya kunye nokutyangokusebenza kwiindlela ze-hypothalamic

• Isincedisi esinokubakho kwiuphando lokutyeba

Iimpawu ze-API (ngeGentolex Group)

• Ukucoceka okuphezulu ≥ 99%(I-HPLC & LC-MS iqinisekisiwe)

• Idityaniswe ngei-soli-phase peptide synthesis (SPPS)

• I-endotoxin ephantsi, izinyibilikisi ezishiyekileyo eziphantsi

• Ifumaneka kwiI-R&D ukuya kwisikali sorhwebo