I-MOTS-C

Inkcazelo emfutshane:

I-MOTS-C API iveliswa phantsi kweemeko ezingqongqo ezifana ne-GMP usebenzisa iteknoloji yesigaba esiqinileyo se-peptide synthesis (SPPS) ukuqinisekisa umgangatho wayo ophezulu, ukucoceka okuphezulu kunye nokuzinza okuphezulu kophando kunye nokusetyenziswa kwezonyango.
Iimpawu zeMveliso:

Ubunyulu ≥ 99% (iqinisekiswe yi-HPLC kunye ne-LC-MS),
I-endotoxin ephantsi kunye nomxholo we-solvent eshiyekileyo,
Iveliswe ngokuhambelana ne-ICH Q7 kunye neeprothokholi ezifana ne-GMP,
Unokufezekisa imveliso enkulu, ukusuka kwi-milligram-level R & D batches ukuya kwi-gram-level kunye ne-kilogram-level unikezelo lwezorhwebo.

Thumela i-imeyile kuthi

Iinkcukacha zeMveliso

Iithegi zeMveliso

MOTS-C API

I-MOTS-C(I-Mitochondrial Open Reading Frame ye-12S rRNA Uhlobo-c) yi-16-amino acid.i-peptide evela kwimitochondria (MDP)ifakwe ngekhowudi yejenome yemitochondrial. Ngokungafaniyo neepeptide zenyukliya ezifakwe kwinyukliya, i-MOTS-c ivela kwingingqi ye-12S rRNA ye-mitochondrial DNA kwaye idlala indima ebalulekileyoukulawula imetabolism yeselula, impendulo yoxinzelelo, kunye novelwano lwe-insulin.

Njengenoveli peptide yonyango,MOTS-c APIuzuze umdla obalulekileyo kwiinkalo zeukuphazamiseka kwemetabolism, ukwaluphala, i-physiology yokuzilolonga, kunye neyeza le-mitochondrial. I-peptide okwangoku iphantsi kophando olunzulu lwe-preclinical kwaye ithathwa njengomgqatswa othembisayoisizukulwana esilandelayo peptide therapeuticskujoliswe kwimpilo yemetabolism kunye nobomi obude.

Indlela yokwenza

I-MOTS-c yenza iziphumo zayo ngei-mitochondrial-nuclear cross-talk-indlela apho i-mitochondria inxibelelana ne-nucleus ukugcina i-homeostasis yeselula. I-peptide ifuduswa isuka kwi-mitochondria iye kwi-nucleus ukuphendula uxinzelelo lwe-metabolic, apho isebenza njengeumlawuli we-metabolicngokuphembelela imbonakalo yemfuza.

Iindlela eziphambili zebhayoloji ziquka:

Ukuqaliswa kwe-AMPK (i-AMP-activated protein kinase):I-MOTS-c ivuselela i-AMPK, inzwa yamandla ephakathi, ikhuthazaUkunyuka kweglucose, i-fatty acid oxidation, kunye ne-mitochondrial biogenesis.
Ukongezwa kwe-insulin sensitivity:I-MOTS-c ikwandisa ukuphendula kwe-insulin kwimisipha kunye nezicubu ze-adipose, ukuphuculai-glucose homeostasis.
Ukunciphisa uxinzelelo lwe-oxidative kunye nokuvuvukala:Ngokumodareyitha ibhalansi ye-redox yeselula kunye neendlela zokubonisa ukuvuvukala.
Ukulawulwa komsebenzi we-mitochondrial kunye ne-biogenesis:Ixhasa impilo ye-mitochondrial, ngakumbi phantsi koxinzelelo okanye iimeko zokuguga.

UPhando loNyango kunye neziphumo zeBiological

Uphononongo lwangaphambi kweklinikhi lubonise uluhlu olubanzi lweziphumo zomzimba kunye nezonyango ze-MOTS-c kuzo zombini iimodeli ze-vitro kunye nezilwanyana:

1. Iziphazamiso zeMetabolic (Ukutyeba kakhulu, udidi lwesi-2 seswekile, ukuxhathisa kwe-insulin)

Ukuphucula ukunyamezela kwe-glucose kunye nokunciphisa amanqanaba eglucose yegazi
Iyaphuculauvakalelo lwe-insulinngaphandle kokunyusa amanqanaba e-insulin
Iyanyusaukunciphisa umzimba kunye ne-fat oxidationkwiimpuku ezityebileyo ezibangelwa kukutya

2. Ukuchasa ukuguga kunye nokuphila ixesha elide

Amanqanaba e-MOTS-c ayancipha kunye nobudala, kunye nokuxhaswa kwiigundane ezikhulileyo kubonisiweukwandisa umthamo womzimba, ukuphucula umsebenzi wemitochondrial, kwayeukulibaziseka ukuhla okunxulumene nobudala.
Ukuphucula ukusebenza komthambo kunyeukunyamezela kwemisiphangokuphucuka kwemetabolism ye-oxidative.

3. IMitochondrial kunye noKhuseleko loxinzelelo lweSelula

Iyaphuculaukusinda kweselula phantsi koxinzelelo lwe-metabolic okanye oxidativeiimeko.
Yandisa imbonakalo yemfuza ehambelana neukulungiswa kweselula kunye ne-autophagy.

4. I-Cardiovascular and Neuroprotective Potential

Uphononongo lokuqala lucebisa ukuba i-MOTS-c inokukhuselaiiseli ze-vascular endothelialkunye nokunciphisa iimpawu zoxinzelelo lwentliziyo.
Iimpawu ezinokuthi zenzeke nge-neuroprotective ngokusebenzisaiindlela ezichasayo kunye ne-antioxidativeziphantsi kophando.

Uveliso lwe-API kunye neempawu zoMgangatho

At Iqela leGentolex, wethuMOTS-c APIiveliswa kusetyenziswai-soli-phase peptide synthesis (SPPS)phantsi kweemeko ezingqongqo ezifana ne-GMP, ukuqinisekisa umgangatho ophezulu, ubunyulu, kunye nokuzinza kuphando kunye nokusetyenziswa kwezonyango.