I-GH/IGF-1 iyancipha ngokwe-physiologically kunye nobudala, kwaye olu tshintsho luhamba kunye nokukhathala, i-muscle atrophy, ukwanda kwezicubu ze-adipose, kunye nokuwohloka kwengqondo kubantu abadala ...
Kwi-1990, uRudman wapapasha iphepha kwiNew England Journal of Medicine eyothusayo uluntu lwezonyango - "Ukusetyenziswa kweHormone yokuKhula koMntu kubantu abangaphezu kweminyaka eyi-60". URudman ukhethe amadoda ali-12 aneminyaka engama-61-81 kulingo lwezonyango:
Emva kweenyanga ze-6 ze-hGH injection, izifundo zine-avareji yokunyuka kwe-8.8% kwi-muscle mass, i-14.4% ekulahlekeni kwamafutha, i-7.11% kwi-skin thickening, i-1.6% kwi-bone density, i-19% kwisibindi kunye ne-17% kwi-spleen xa kuthelekiswa neqela lokulawula labanye abantu abadala abaneminyaka efanayo. %, kwaye kwagqitywa ekubeni iinguqu ze-histological kuzo zonke izifundo zazineminyaka eli-10 ukuya kwengama-20 ubudala.
Esi sigqibo sikhokelele ekunyusweni ngokubanzi kwehomoni yokukhula komntu (rhGH) njengechiza elichasa ukwaluphala, kwaye ikwangunobangela wenkolelo yabantu abaninzi yokuba inaliti ye-rhGH inokuchasa ukwaluphala. Ukususela ngoko, oogqirha abaninzi baye basebenzisa i-hGH njengeyeza elichasayo, nangona lingavunywanga yi-FDA.
Nangona kunjalo, njengoko uphando luqhubeka luba nzulu, izazinzulu ziye zafumanisa ukuba izibonelelo ezincinci kumzimba wokwandisa umsebenzi we-GH / IGF-1 axis azinakwandisa ixesha lokuphila kwabantu abadala, kodwa endaweni yoko zibeka ingozi kwimpilo:
Iigundane ezigqithisa i-GH zinkulu, kodwa zine-30% -40% ubude obufutshane kuneegundane zasendle [2], kunye notshintsho lwe-histopathological (glomerulosclerosis kunye ne-hepatocyte proliferation) zenzeke kwiigundane ezinamazinga e-GH aphakamileyo. enkulu) kunye nokumelana ne-insulin.
Amanqanaba aphezulu e-GH akhuthaza ukukhula kwemisipha, amathambo, kunye nezitho zangaphakathi, ezikhokelela kwi-gigantism (kubantwana) kunye ne-acromegaly (kubantu abadala). Abantu abadala abane-GH engaphezulu bahlala bedibene nesifo sikashukela kunye neengxaki zentliziyo, kunye nomngcipheko ophezulu womhlaza.
Ixesha lokuposa: Jul-22-2022