Wazi kangakanani nge-GLP-1?

1. Inkcazo ye-GLP-1

IGlucagon-Like Peptide-1 (GLP-1) yihomoni eyenzeka ngokwemvelo eveliswa emathunjini emva kokutya. Idlala indima ebalulekileyo kwimetabolism yeglucose ngokuvuselela ukukhuselwa kwe-insulin, inqanda ukukhutshwa kweglucagon, ukucotha ukuphuma kwesisu, kunye nokukhuthaza ukuziva ukuhlutha. Ezi ziphumo ezidibeneyo zinceda ukulawula amanqanaba eswekile yegazi kunye negalelo ekulawuleni ubunzima. I-Synthetic GLP-1 receptor agonists ilinganisa ezi nkqubo zendalo, zibenza zixabiseke kunyango lwe-2 yeswekile kunye nokukhuluphala.

2. Ukuhlelwa ngokoMsebenzi

Ngokusekwe kwiindima zayo zomzimba, i-GLP-1 kunye ne-analog yayo inokwahlulwa ngokweendidi ezininzi zokusebenza:

• Ulawulo lweswekile yegazi: Yandisa ukukhutshwa kwe-insulin ekuphenduleni amanqanaba aphezulu eglucose ngelixa icinezela ukukhutshwa kweglucagon.
• Ukulawulwa kokutya: Isebenza kwiziko lokutya kwengqondo ukunciphisa ukutya kunye nokwandisa ukuhlutha.
• Ukulawulwa kweGastrointestinal: Yehlisa ukukhupha isisu, ukwandisa inkqubo yokugaya kunye nokunceda ukulawula i-postprandial glucose spikes.
• Izibonelelo ze-cardiovascular: Ezinye i-GLP-1 receptor agonists ziye zaboniswa ukunciphisa umngcipheko weziganeko ezinkulu zentliziyo kwizigulane zesifo seswekile.
• Ulawulo lobunzima: Ngokunqanda ukuthanda ukutya kunye nokukhuthaza ukuncitshiswa kweekhalori, iianalogu ze-GLP-1 zixhasa ukwehla kobunzima kancinci kancinci.

3. Iimpawu ze-GLP-1
I-GLP-1 inesiqingatha sobomi obufutshane kakhulu bendalo-imizuzu nje embalwa-kuba iyancipha ngokukhawuleza i-enzyme DPP-4 (dipeptidyl peptidase-4). Ukoyisa oku, abaphandi bamayeza baphuhlise i-GLP-1 receptor agonists esebenza ixesha elide njenge.Semaglutide, ILiraglutide, Tirzepatide, kwayeRetatrutide.

Ezi khompawundi zilungisiwe zandisa umsebenzi ukusuka kwiiyure ukuya kwiintsuku okanye kwiiveki, zivumela idosi kanye ngemini okanye kanye ngeveki.
Iimpawu eziphambili ziquka:

• Isenzo esixhomekeke kwiGlucose: Yehlisa umngcipheko we-hypoglycemia xa kuthelekiswa nonyango lwe-insulin yemveli.
• Iindlela ezimbini okanye ezintathu (kumachiza amatsha): Ezinye iinguqulelo eziphambili zijolise kwii-receptors ezongezelelweyo ezifana ne-GIP okanye i-glucagon receptors, eziphucula izibonelelo ze-metabolic.
• Uphuculo olubanzi lwe-metabolic: Yehlisa i-HbA1c, iphucula iprofayili ye-lipid, kwaye ixhasa ukunciphisa umzimba.

I-GLP-1 kunye ne-analogs yayo iguqule unyango lwangoku lwe-metabolic ngokujongana nesifo seswekile kunye nokutyeba ngaxeshanye-ukubonelela kungekuphela nje ukulawula iswekile yegazi kodwa kunye neenzuzo zentliziyo kunye nobunzima bexesha elide.

4.Izisombululo zonyango lwe-GLP-1

5. I-Injectable GLP-1 Receptor Agonists
Ifomu yokuhanjiswa kwesiqhelo, ezi ziquka iLiraglutide, iSemaglutide, kunye neTirzepatide. Zilawulwa ngaphantsi kwe-subcutaneously, mhlawumbi imihla ngemihla okanye ngeveki, ukubonelela ngokuqhubekayo i-receptor activation yokulawula i-glucose ezinzileyo kunye nokunciphisa ukutya.

5. Oral GLP-1 Receptor Agonists
Inketho entsha, efana ne-Oral Semaglutide, inikezela izigulane ezingenaliti. Isebenzisa iteknoloji yokuphucula i-absorption ukugcina i-bioavailability xa ithathwa ngomlomo, ukuphucula ukuthotyelwa konyango.

6. Unyango oludityanisiweyo (GLP-1 + Ezinye iindlela)
Unyango olusakhulayo ludibanisa i-GLP-1 kunye ne-GIP okanye i-glucagon receptor agonism ukuphumeza ukwehla kobunzima obunamandla kunye neziphumo ze-metabolic. Ngokomzekelo, i-Tirzepatide (i-agonist ye-GIP / GLP-1) kunye ne-Retatrutide (i-triple GIP / GLP-1 / glucagon agonist) imele isizukulwana esilandelayo sonyango lwe-metabolic.

Unyango lwe-GLP-1 lubonisa inyathelo eliguqukayo ekulawuleni izifo ezingapheliyo ze-metabolic-inika indlela edibeneyo yokulawula iswekile yegazi, ukunciphisa ubunzima, kunye nokuphucula iziphumo zempilo ngokubanzi.