I-MOTS-c: I-Peptide ye-Mitochondrial eneziNzuzo zeMpilo ezithembisayo

I-MOTS-c (iMitochondrial Open Reading Frame ye-12S rRNA Type-c) yipeptide encinci efakwe kwi-DNA ye-mitochondrial ethe yatsala umdla obalulekileyo wesayensi kwiminyaka yakutshanje. Ngokwesiko, i-mitochondria ijongwe ngokuyintloko njenge "ndlu yamandla yeseli," enoxanduva lokuvelisa amandla. Nangona kunjalo, uphando oluvelayo lubonisa ukuba i-mitochondria iphinda isebenze njengeendawo zokubonisa, ukulawula imetabolism kunye nempilo yeselula ngokusebenzisa i-peptides ye-bioactive efana ne-MOTS-c.

Le peptide, equka nje i-16 amino acids, ifakwe kwikhowudi ngaphakathi kwe-12S rRNA ummandla we-mitochondrial DNA. Emva kokuba ihlanganiswe kwi-cytoplasm, inokutshintshela kwi-nucleus, apho ichaphazela ukubonakaliswa kweejene ezibandakanyekayo kulawulo lwe-metabolic. Enye yeendima zayo ezibaluleke kakhulu kukuvula indlela yokubonisa i-AMPK, ephucula ukunyuswa kwe-glucose kunye nokusetyenziswa ngelixa uphucula uvakalelo lwe-insulin. Ezi zakhiwo zenza i-MOTS-c ibe ngumgqatswa othembisayo wokujongana nokuphazamiseka kwemetabolism efana nohlobo lwe-2 yeswekile kunye nokutyeba.

Ngaphandle kwe-metabolism, i-MOTS-c ibonise iziphumo zokukhusela kwixinzelelo lwe-oxidative ngokomeleza ukukhusela i-cell cell kunye nokunciphisa umonakalo obangelwa yi-radicals yamahhala. Lo msebenzi unegalelo ekugcineni impilo yezitho ezibalulekileyo ezifana nentliziyo, isibindi, kunye nenkqubo ye-nervous. Uphando luye lwagxininisa ikhonkco elicacileyo phakathi kwamanqanaba e-MOTS-c kunye nokuguga: njengoko umzimba ukhula, amanqanaba endalo e-peptide ayancipha. Ukongezwa kwizifundo zezilwanyana kuye kwaphucula ukusebenza komzimba, ukulibazisa ukuhla okunxulumene neminyaka yobudala, kunye nokwandisa ubomi, ukuphakamisa amathuba okuba i-MOTS-c iphuhliswe "njenge-molecule echasene nokuguga."

Ukongezelela, i-MOTS-c ibonakala iphakamisa amandla e-muscle metabolism kunye nokunyamezela, okwenza kube nomdla omkhulu kumayeza ezemidlalo kunye nokuvuselelwa. Olunye uphononongo lukwacebisa iingenelo ezinokubakhona kwizifo ze-neurodeergenerative, ukwandisa ngakumbi i-horizon yayo yonyango.

Nangona isekumanqanaba okuqala ophando, i-MOTS-c imele impumelelo ekuqondeni kwethu ibhayoloji ye-mitochondrial. Ayiceli nje umngeni kwimbono eqhelekileyo ye-mitochondria kodwa ikwavula iindlela ezintsha zokunyanga izifo ze-metabolic, ukunciphisa ukuguga, kunye nokukhuthaza impilo yonke. Ngokufunda ngakumbi kunye nophuhliso lwezonyango, i-MOTS-c inokuba sisixhobo esinamandla kwixesha elizayo leyeza.