I-Retatrutide: Inkwenkwezi Ekhulayo Enokuguqula Ukutyeba kakhulu kunye noNyango lweSifo seswekile

Kwiminyaka yakutshanje, ukunyuka kwamachiza e-GLP-1 anjenge-semaglutide kunye ne-tirzepatide kubonakalise ukuba ukwehla kobunzima obukhulu kunokwenzeka ngaphandle kotyando. Ngoku,Retatrutide, i-agonist i-receptor agonist ephuhliswe ngu-Eli Lilly, idonsa ingqalelo yehlabathi jikelele kuluntu lwezonyango kunye nabatyalo-mali ngokufanayo ngenxa yokukwazi ukuhambisa iziphumo ezinkulu ngakumbi ngokusebenzisa indlela ekhethekileyo yokwenza.

UkuPhumelela kweNdlela yeeThagethi ezininzi

I-Retatrutide ivelele kuyoukusebenza ngaxeshanye kwama-receptors amathathu:

• I-GLP-1 i-receptor-Icinezela umdla wokutya, icothisa ukukhupha isisu, kwaye iphucula ukukhuselwa kwe-insulin

• GIP receptor-Ukonyusa ngakumbi ukukhutshwa kwe-insulin kunye nokwenza ngcono i-glucose metabolism

• IGlucagon receptor-Yandisa inqanaba le-basal metabolic, ikhuthaza ukuqhekeka kwamafutha, kwaye yonyusa inkcitho yamandla

Le ndlela "yesenzo esiphindwe kathathu" ayixhasi nje ukulahleka kobunzima obuninzi kodwa iphucula imiba emininzi yempilo ye-metabolic, kubandakanywa nokulawulwa kwe-glucose, iprofayili ye-lipid, kunye nokunciphisa amafutha esibindi.

Iziphumo ezichukumisayo zeklinikhi zakwaQala

Kulingo lokuqala lweklinikhi, abantu abangenasifo seswekile abatyebe kakhulu abathathe iRetatrutide malunga neeveki ezingama-48 babona.i-avareji yokwehla kobunzima obungaphezulu kwe-20%, kunye nabanye abathathi-nxaxheba abaphumelele phantse i-24%-esondela ekusebenzeni kotyando lwe-bariatric. Phakathi kwabantu abanesifo seswekile esi-2, ichiza alizange linciphise kakhulu amanqanaba e-HbA1c kuphela kodwa likwabonise amandla okuphucula imeko yentliziyo kunye ne-metabolic risk.

Amathuba kunye nemingeni engaphambili

Ngelixa i-Retatrutide ibonisa isithembiso esimangalisayo, isekwisigaba sesi-3 solingo lwezonyango kwaye akunakwenzeka ukuba ifike kwimarike ngaphambili.2026–2027. Nokuba ingaba ngokwenene "ngumtshintshi-mdlalo" kuya kuxhomekeka:

1. Ukhuseleko lwexesha elide– Ukubeka iliso kwiziphumo ebezingalindelekanga ezitsha okanye ezandisiweyo xa kuthelekiswa namachiza akhoyo e-GLP-1

2. Ukunyamezela kunye nokubambelela- Ukumisela ukuba ngaba ukusebenza okuphezulu kuza kwiindleko eziphezulu zokuyeka

3. Ukusebenza korhwebo– Amaxabiso, ukhuselo lwe-inshurensi, kunye nokwahlula okucacileyo kwiimveliso ezikhuphisanayo

Impembelelo yeMarike enokwenzeka

Ukuba i-Retatrutide inokufikelela kwibhalansi elungileyo phakathi kokhuseleko, ukusebenza kakuhle, kunye nokufikeleleka, inokumisela umgangatho omtsha wamayeza okunciphisa umzimba kwaye ityhale ukutyeba kunye nonyango lweswekile kwixeshaUngenelelo oluchanekileyo olujoliswe kwizinto ezininzi-ngokunokwenzeka ukuhlengahlengisa yonke imakethi yesifo semetabolism yehlabathi.