IXESHA laseCanada 2022-01-24, i-Rhovac, inkampani yamayeza igxile kwi-tumor i-turum ye-turust ye-RV001 eya kugunyaziswa yi-Ofisi yePropathi ye-Canada (CIO). Ngaphambili, inkampani ifumene amalungelo obunikazi enxulumene ne-RV001 eUnited States, eYurophu naseJapan. Esi sibonelelo sechiza sepatent siya kubonelela ngokhuseleko ngokubanzi nge-RV001 kwiimarike eziphambili kwaye iphakamise izithintelo zepatent zePatent.
Njengo-Patent olwenziweyo, eli patent ligubungela ugonyo lwe-RV001 kunye neendawo ezahlukeneyo, kunye nokusetyenziswa kwayo kunyango / kunyango lwe-Rhoc-ivele ngokubonisa umhlaza wesitavatitity. Phakathi kwazo, i-RHOC i-turus-in antigen (i-TAA) ye-ostieted kwiindidi ezahlukeneyo zeseli. Nje ukuba, ilungelo elilodwa lomenzi wechiza liya kuphelelwa ngo-2028-12 kwaye kulindeleke ukuba longezwe ekufumaneni isatifikethi sokukhusela (CSP).
I-01 Anilcamotide
I-Anilicamotide ngumhlaza wogonyo olwenziwe nge-gonogenic ye-ranogenic ilungu losapho lwe-ramogous ye-C (RHOC), enokuthi isuswe kwi-Mnumsunside yase-I-ISA-51, ngeMisebenzi ye-antitUmer. Ulawulo lwe-Anicaneaneous of Anilcamotide luvuselela amajoni omzimba omzimba ukonga i-humoral kunye ne-cytotocy t lymphocyte (ctl) phendula kwiiseli ze-rumoc, ngaloo ndlela ziphuma kwiiseli zethumba.
2020-11, i-RV001 inikwe umkhondo okhawulezayo nge-FDA.
Iimvavanyo zeklinikhi ze-02
Ngo-2018, isigaba se-IIA IXESHA LOKUGQIBELA LWE-AITICATIONOOTIONO Ukuvunywa koMhlaza we-Prestate wavunywa, kwaye uninzi lwezigulana zabhaliswa. Iziphumo zibonise ukuba i-ailcamotide ikhuselekile kwaye inyamezeleke kakuhle. Ukongeza, izigulana zaphuhliswa iimpendulo ezinamandla nezihlala zomeleleyo. Ngowama-2021, ukulandelwa kwe-19 kwezi pesenti kamva emva kokugqitywa konyango yiRhovac, kubonakalise ukuba ezi zifundo azikhange ziphuhlise nakuphi na ukuphathwa kwe-metastases okanye ifumene uqeqesho olungaphezulu lwe-Antign (PA). . Kwezi zinto, izifundo ezili-16 zazingenasipho-sithi, kwaye izifundo ezi-3 zihamba kancinci inkqubela phambili. I-PSA yiprotheyini eveliswa yi-Grostate Gland kwaye isetyenziselwa ukulandelela ukuqhubela phambili komhlaza owaziwayo owaziwayo.
Ngo-2019, i-RV001 IIB I-IIB I-Bravac (i-In] I-Prestarial, ilawulwa i-POPECO) yasungulwa okanye inqunyulwe ukuphuculwa komhlaza we-metastatic prostry emva kotyando / imitha. Oluvavanyo lweklinikhi lwe-IIB luphawu lokufumana izifundo zelizwe liphela, kumazwe amaninzi okufunda kumazwe angama-6 aseYurophu (iDenmark, iFinmark, iSweden, iBelgium, ne-United States) kunye ne-United States. Ityala eligqityiweyo lokufumana ukufunyanwa kwezigulana ngo-2021-09, zizonke malunga nezifundo ezili-175 ezibhalisiweyo, kwaye ziya kuphela ngo-2022H1. Ukongeza, izicwangciso ze-Rhovac zokuqhuba iSifundo esiPhakamisayo esijolise ekunikezeleni ubungqina obubonisa ubungqina bokwanda kwe-RV001 kwizibonakaliso.
Ukongeza, iKomiti yokubeka esweni ukhuseleko iqhube kuqhubekile kwi-RV001 ngo-2021-07, kwaye akukho minyhadala imbi engalindelekanga ifunyenwe, eyayihambelana neziphumo zangaphambili i / I
IXESHA LOKUQALA: FEB-17 ukuya ku-1722