Njenge-agonist ye-GLP-1, ilinganisa iziphumo ze-physiological ze-GLP-1 ekhutshwe ngokwemvelo emzimbeni.
Ukuphendula kwi-glucose intake, i-PPG neurons kwinkqubo ye-nervous central (CNS) kunye neeseli ze-L emathunjini zivelisa kwaye zikhuphe i-GLP-1, i-hormone ye-inhibitory gastrointestinal.
Emva kokuba ikhutshiwe, i-GLP-1 yenza i-GLP-1R isebenze i-receptors kwi-pancreatic β-cell, iqala uchungechunge lweenguqu ze-metabolic ezibonakaliswa ukukhuselwa kwe-insulin kunye nokunyanzeliswa kokutya.
Ukukhutshwa kwe-insulin kukhokelela ekunciphiseni ngokubanzi amanqanaba eswekile yegazi, ukwehla kwemveliso yeglucagon, kunye nokuthintela ukukhutshwa kweglucose kwiivenkile ze-glycogen zesibindi. Oku kubangela ukuhlutha, kuphucula ukuvakalelwa kwe-insulin, kwaye ekugqibeleni kubangele ukwehla kobunzima.
Ichiza livuselela ukukhutshwa kwe-insulin ngendlela exhomekeke kwi-glucose, ngaloo ndlela inciphisa umngcipheko we-hypoglycemia. Ukongezelela, ineempembelelo ezintle zexesha elide ekusindeni, ukwanda, kunye nokuhlaziywa kweeseli ze-β.
Uphando lubonisa ukuba i-semaglutide ngokuyintloko ilinganisa iziphumo ze-GLP-1 ezikhutshwe emathunjini kunokuba zisuka kwingqondo. Oku kungenxa yokuba uninzi lwee-receptors ze-GLP-1 ebuchotsheni zilele ngaphandle koluhlu olusebenzayo lwala machiza alawulwa ngokwenkqubo. Ngaphandle kwesenzo esincinci esithe ngqo kwi-brain GLP-1 receptors, i-semaglutide ihlala isebenza kakhulu ekunciphiseni ukutya kunye nobunzima bomzimba.
Kubonakala kufezekisa oku ngokuvula uthungelwano lwe-neuronal kuyo yonke inkqubo ye-nervous central, uninzi lwazo iithagethi zesibini ezingavezi ngokuthe ngqo i-GLP-1 receptors.
Kwi-2024, iinguqulelo ezivunyiweyo zorhwebo ze-semaglutide zibandakanyaOzempic, Rybelsus, kwayeWegovyiinaliti, zonke ziphuhliswe nguNovo Nordisk.
Ixesha lokuposa: Aug-18-2025