Kwiminyaka yakutshanje, i-GLP-1 receptor agonists iye yanda ngokukhawuleza ukusuka kunyango lweswekile ukuya kwizixhobo zokulawula ubunzima, ibe lelinye lawona macandelo ajongwe kakhulu kumayeza ehlabathi. Ukusukela phakathi ku-2025, lo mfutho awubonakalisi uphawu lokucotha. Iingxilimbela zemizi-mveliso u-Eli Lilly kunye noNovo Nordisk babandakanyeka kukhuphiswano olunzulu, iinkampani zamayeza aseTshayina ziyanda kumazwe ngamazwe, kwaye iithagethi ezintsha kunye nezalathisi ziyaqhubeka nokuvela. I-GLP-1 ayiselilo nje icandelo lamachiza-iyatshintsha ibe liqonga elibanzi lolawulo lwezifo zemetabolism.
I-tirzepatide ka-Eli Lilly iye yazisa iziphumo ezikhangayo kwiimvavanyo ezinkulu zeklinikhi ye-cardiovascular, ebonisa kungekuphela nje ukusebenza okuzinzileyo kwiswekile yegazi kunye nokunciphisa ubunzima, kodwa kunye nokhuseleko oluphezulu lwentliziyo. Uninzi lwabakhi-mkhanyo kwishishini bakubona oku njengesiqalo “sesibini sokukhula kwegophe” kunyango lwe-GLP-1. Okwangoku, i-Novo Nordisk ijongene ne-headwinds-intengiso ecothayo, ukuhla kwemivuzo, kunye nenguqu yobunkokeli. Ukhuphiswano kwisithuba se-GLP-1 lutshintshile ukusuka “kwimfazwe ye-blockbuster” ukuya kugqatso olupheleleyo lwe-ecosystem.
Ngaphaya kwezitofu, umbhobho uyahluka. Ukuqulunqwa komlomo, iimolekyuli ezincinci, kunye neendlela zonyango ezidibeneyo ziphantsi kokuphuhliswa kweenkampani ezininzi, zonke zijolise ekuphuculeni ukuthotyelwa kwesigulane kwaye zivelele kwimarike egcwele abantu. Kwangaxeshanye, iifemu zamachiza zaseTshayina zithe cwaka zisenza buvakale ubukho bazo, zifumana amalinge emvumelwano kumazwe ngamazwe axabisa iibhiliyoni zeerandi—uphawu lwamandla akhulayo eTshayina kuphuhliso lwamachiza olutsha.
Okubaluleke ngakumbi, amachiza e-GLP-1 ahamba ngaphaya kokutyeba kunye nesifo seswekile. Izifo zentliziyo, isifo sesibindi esinamafutha (NAFLD), isifo se-Alzheimer, umlutha, kunye nokuphazamiseka kokulala ngoku ziphantsi kophando, kunye nobungqina obuninzi obubonisa amandla onyango lwe-GLP-1 kwezi ndawo. Ngelixa uninzi lwezi zicelo zisekwinqanaba lokuqala leklinikhi, zitsala utyalo-mali olubalulekileyo kuphando kunye nomdla oyinkunzi.
Nangona kunjalo, ukwanda kokuthandwa konyango lwe-GLP-1 kuzisa iinkxalabo zokhuseleko. Iingxelo zamva nje ezinxibelelanisa ukusetyenziswa kwexesha elide le-GLP-1 kwimiba yamazinyo kunye neemeko zemithambo-luvo ezinqabileyo zamehlo ziye zaphakamisa iiflegi ezibomvu phakathi koluntu kunye nabalawuli. Ukulungelelanisa ukusebenza ngempumelelo kunye nokhuseleko kuya kubaluleka kuhlumo loshishino oluzinzileyo.
Zonke izinto eziqwalaselweyo, i-GLP-1 ayiseyiyo nje indlela yonyango-isele yaba yindawo ephambili yedabi kugqatso lokuchaza ikamva lempilo ye-metabolic. Ukusuka kubuchule besayensi ukuya kuphazamiseko lwentengiso, ukusuka kwiifomathi zokuhanjiswa ezintsha ukuya kwizicelo zezifo ezibanzi, i-GLP-1 ayilochiza nje-lithuba lokuvelisa.
Ixesha lokuposa: Aug-01-2025