Inkqubela phambili yophando ye-opioid ye-opioid isuka kwimvume ye-Diflikefalin

Kwangoko i-2021-08-24, i-Cara Preser kunye ne-vifor yakhe yeShishini i-Vifodi ye-Kappa Oppres ye-Agodist ye-Agonist Fiegel 20222Q1. I-Cara kunye ne-vifor zisayine isivumelwano selayisensi ekhethekileyo yokurhweba kwi-Korsuva ™ e-United States kwaye savuma ukuthengisa iKaorsenius. Phakathi kwawo, i-Cara ne-vifor nganye ine-60% ne-40% yenzuzo yengeniso kwingeniso yentengiso ngaphandle kwe-fresenius yezonyango; Umntu ngamnye unenzuzo ye-50% yengeniso kwingeniso yokuthengisa evela kwi-fresenius yezonyango.

I-CKD-enxulumene (i-CKD-AP) ye-purritus eqhelekileyo eyenzeka rhoqo kunye nobunzulu kwizigulana ze-CKD zijonga i-dialysis. I-Pruritus yenzeka malunga ne-60% -70% yezigulana ezifumana i-diylysis, apho i-30% -40% inobumoyike / i-Irritus enkulu, echaphazela kakhulu ubomi obungalunganga) kwaye inxulunyaniswa nokudakumba. Akukho nyango lusebenzayo lwe-CKD Pruritus ngaphambili, kwaye ukuvunywa kwe-diflikefalin kuyanceda ukujongana ne-Great ye-Gap. Oku kuvunywa kusekwe kwiimvavanyo zeklinikhi ezimbini ze-pivotal yesigaba se-NDA: Idatha eyakhayo evela kwi-Kal-1 yedatha ye-NARMICS kwi-32 ye-Narsuva ™ inyamezele kakuhle.

Kungekudala, iindaba ezimnandi zavela kwisifundo seklinikhi ye-Difelkefalin eJapan: 2022-1-10, uCara wabhengeza ukuba inaliti isetyenziswa i-puritsin kwizigulana ze-themodialysis kwizigulo ze-themodialysis kwizigulo ze-themodialysis kwizigulo ze-themodialysis kwizigulo ze-hemodialysis kwizigulo ze-themodialysis kwizigulo ze-themodialysis kwizigulo ze-themodialysis kwizigulo ze-themodialys. Inqanaba lesigaba seklinikhi Izilingo abaziphethe kakuhle zafezekiswa. Izigulana ezili-178 zifumene iiveki ezi-6 ze-difdekefallalin okanye i-placebo kwaye zithathe inxaxheba kwiveki ezingama-52 evulekileyo yokuvula ilebhile evulekileyo. Isiphelo esiphambili (utshintsho eRuritus Manatial Dat) kunye nePhezulu le-ITCHit kwi-Shicrarari Seversity) baphuculwe kakhulu kwiqela lesiseko kwiqela le-phlikefalin kwaye banyamezelwe kakuhle.

I-Dimelliefalin yiklasi ye-opioid peptides. Ngokusekwe koku, iZiko loPhando lwePeptiide lifunde uncwadi kwi-Opioid Peptides, kwaye lashwankathela ubunzima kunye nezicwangciso-qhinga ze-Opioid kwi-PitPides ekuphuhlisweni kweziyobisi, kunye nemeko yangoku yokuphucula iziyobisi.