Yintoni i-NAD + kwaye kutheni ibaluleke kakhulu kwiMpilo kunye noBomi obude?

I-NAD⁺ (I-Nicotinamide Adenine Dinucleotide) yi-coenzyme eyimfuneko ekhoyo phantse kuzo zonke iiseli eziphilayo, ezidla ngokubizwa ngokuba "yimolekyuli engundoqo ye-cell vitality." Isebenza iindima ezininzi emzimbeni womntu, isebenza njengomphathi wamandla, umgcini wozinzo lwemfuza, kunye nomkhuseli womsebenzi weselula, iyenza ibaluleke kakhulu ekugcineni impilo kunye nokulibazisa ukuguga.

Kwimetabolism yamandla, i-NAD⁺ iququzelela ukuguqulwa kokutya kube ngamandla asebenzisekayo. Xa i-carbohydrates, amafutha, kunye neeprotheni zichithwa ngaphakathi kweeseli, i-NAD⁺ isebenza njenge-electron carrier, idlulisela amandla kwi-mitochondria ukuqhuba imveliso ye-ATP. I-ATP isebenza njenge "fuel" kwimisebenzi yeselula, inika amandla kuzo zonke iinkalo zobomi. Ngaphandle kwe-NAD⁺ eyaneleyo, ukuveliswa kwamandla eselula kuyehla, okukhokelela ekunciphiseni amandla kunye nokusebenza ngokubanzi.

Ngaphandle kwe-metabolism yamandla, i-NAD⁺ idlala indima ephambili ekulungiseni i-DNA kunye nokuzinza kwe-genomic. Iiseli zihlala zibonakaliswe kumonakalo we-DNA kwizinto ezisingqongileyo kunye ne-metabolic byproducts, kwaye i-NAD⁺ ivula i-enzyme yokulungisa ukulungisa ezi mpazamo. Ikwavula ii-sirtuins, usapho lweeprotheyini ezinxulumene nobomi obude, umsebenzi we-mitochondrial, kunye nokulinganisela kwe-metabolic. Ke, i-NAD⁺ ayibalulekanga kuphela ekugcineni impilo kodwa ikwajolisa kuphando lokuchasa ukwaluphala.

I-NAD⁺ ikwabalulekile ekuphenduleni uxinzelelo lweselula kunye nokukhusela inkqubo yemithambo-luvo. Ngexesha loxinzelelo lwe-oxidative okanye ukudumba, i-NAD⁺ inceda ukulawula ukubonakaliswa kweselula kunye ne-ion balance ukugcina i-homeostasis. Kwinkqubo ye-nervous, ixhasa impilo ye-mitochondrial, inciphisa umonakalo we-oxidative kwi-neurons, kwaye inceda ukulibazisa ukuqala kunye nokuqhubela phambili kwezifo ze-neurodeergenerative.

Nangona kunjalo, amanqanaba e-NAD⁺ ngokwendalo aye ehla ngobudala. Oku kuncipha kudibaniswa nokunciphisa imveliso yamandla, ukulungiswa kwe-DNA ephazamisekileyo, ukunyuka kokuvuvukala, kunye nokuncipha komsebenzi we-neural, zonke ezo ziyimpawu zokuguga kunye nesifo esingapheliyo. Ukugcina okanye ukonyusa amanqanaba e-NAD⁺ ke ngoko kube yeyona nto iphambili ekugxilwe kuyo kulawulo lwezempilo lwangoku kunye nophando lobomi obude. Izazinzulu ziphonononga ukongezwa kunye ne-NAD⁺ precursors efana ne-NMN okanye i-NR, kunye neendlela zokuphila, ukugcina amanqanaba e-NAD⁺, ukomeleza amandla, kunye nokukhuthaza impilo yonke.