I-Retatrutide yi-agonist ekhulayo ye-multi-receptor, isetyenziselwa ukunyanga ukutyeba kunye nezifo ze-metabolic. Inokuthi ngaxeshanye isebenze ezintathu ze-incretin receptors, kubandakanywa i-GLP-1 (i-glucagon-like peptide-1), i-GIP (i-glucose-exhomekeke kwi-insulinotropic polypeptide) kunye ne-glucagon receptor. Le ndlela ininzi yenza i-retatrutide ibonise amandla amakhulu kulawulo lobunzima, ulawulo lweswekile yegazi kunye nempilo yonke ye-metabolic.
Iimpawu eziphambili kunye neziphumo ze-retatrutide:
1. Iindlela ezininzi zokusebenza:
(1) I-GLP-1 i-receptor agonism: I-Retatrutide ikhuthaza ukukhutshwa kwe-insulin kwaye inqanda ukukhululwa kweglucagon ngokuvula i-GLP-1 receptors, ngaloo ndlela inceda ukunciphisa iswekile yegazi, ukulibazisa ukukhutshwa kwesisu kunye nokunciphisa ukutya.
(2) I-GIP receptor agonism: I-GIP i-receptor agonism inokuphucula ukukhutshwa kwe-insulin kwaye incede ngakumbi ukuthoba iswekile yegazi.
2. I-Glucagon receptor agonism: I-Glucagon receptor agonism inokukhuthaza ukubola kwamafutha kunye ne-metabolism yamandla, ngaloo ndlela inceda ukunciphisa umzimba.
3. Isiphumo esibalulekileyo sokulahlekelwa kwesisindo: I-Retaglutide ibonise imiphumo ebalulekileyo yokulahlekelwa kwesisindo kwizifundo zeklinikhi kwaye ifanelekile ngokukodwa kwizigulane ezigqithiseleyo okanye izigulane ezine-syndrome ye-metabolic syndrome. Ngenxa yeendlela ezininzi zokwenza, inomsebenzi obalaseleyo ekunciphiseni amanqatha omzimba kunye nokulawula ubunzima.
4. Ukulawulwa kweswekile yegazi: I-Retaglutide inokunciphisa ngokufanelekileyo amanqanaba eswekile yegazi kwaye ifanelekile ngokukodwa kwizigulane ezinesifo sikashukela sohlobo lwe-2 olufuna ukulawula iswekile yegazi. Inokunceda ukuphucula uvakalelo lwe-insulin kunye nokunciphisa ukuguquguquka kweswekile ye-postprandial.
5. Ubunako bempilo ye-cardiovascular: Nangona i-retaglutide isekwinqanaba lophando lwezonyango, idatha yangaphambili ibonisa ukuba inokuba namandla okunciphisa umngcipheko weziganeko ze-cardiovascular, ezifana nokukhuselwa kwentliziyo kwamanye amachiza e-GLP-1.
6. Ukulawulwa kwe-injection: I-Retaglutide okwangoku ilawulwa nge-injection subcutaneous, ngokuqhelekileyo njengendlela yokuqulunqwa kwexesha elide kanye ngeveki, kwaye le ngqungquthela ye-dosing inceda ukuphucula ukuthotyelwa kwesigulane.
7. Imiphumo emibi: Imiphumo eqhelekileyo ibandakanya iimpawu zesisu ezifana ne-nausea, ukuhlanza kunye nohudo, kufana nemiphumo yezinye iziyobisi ze-GLP-1. Ezi mpawu zixhaphake kakhulu kumanqanaba okuqala onyango, kodwa izigulana zihlala ziziqhelanisa ngokuthe ngcembe njengoko ixesha lonyango lisanda.
Uphando lwezonyango kunye nokusetyenziswa:
I-Retaglutide isephantsi kovavanyo olukhulu lweklinikhi, ngakumbi ukuvavanya iziphumo zayo zexesha elide kunye nokhuseleko kunyango lokutyeba. Iziphumo zolingo lwezonyango lwakwangoko zibonisa ukuba iyeza linempembelelo enkulu ekulahlekeni kobunzima kunye nokuphucula impilo yemetabolism, ngakumbi kwizigulane ezineziphumo ezilinganiselweyo zamachiza esintu.
I-Retaglutide ithathwa njengoluhlobo olutsha lweziyobisi ze-peptide ezinamandla amakhulu okusebenza kunyango lokukhuluphala, isifo se-metabolic kunye nohlobo lwe-2 yeswekile. Ngokupapashwa kwedatha yolingo oluthe kratya lwezonyango kwixesha elizayo, kulindeleke ukuba ibe lelinye iyeza lempumelelo kunyango lokutyeba kakhulu kunye nezifo ze-metabolic.
Ixesha lokuposa: May-27-2025