Plozasiran

I-Plozasiran (API)

Isicelo soPhando:
I-Plozasiran API yi-RNA encinci ephazamisayo (i-siRNA) ephuhliselwe unyango lwe-hypertriglyceridemia kunye ne-cardiovascular and metabolic disorders. Ijolise kwiAPOC3gene, efaka i-apolipoprotein C-III, umlawuli oyintloko we-triglyceride metabolism. Kuphando, i-Plozasiran isetyenziselwa ukufunda izicwangciso ze-RNAi-based based lipid-downing, i-gene-sincing specificity, kunye nonyango oluthatha ixesha elide kwiimeko ezifana ne-familial chylomicronemia syndrome (FCS) kunye ne-dyslipidemia edibeneyo.

Umsebenzi:
Plozasiran imisebenzi ngokuthulisaAPOC3I-mRNA esibindini, ekhokelela ekunciphiseni amanqanaba e-apolipoprotein C-III. Oku kukhuthaza i-lipolysis ephuculweyo kunye nokususwa kwe-triglyceride-rich lipoprotein ukusuka egazini. Njenge-API, i-Plozasiran yenza ukuphuhliswa kweendlela zokwelapha ezithatha ixesha elide ezijoliswe ekunciphiseni kakhulu amanqanaba e-triglyceride kunye nokunciphisa umngcipheko we-pancreatitis kunye neziganeko ze-cardiovascular kwizigulane ezineengxaki ezinzima okanye ze-genetic lipid.