Iimveliso
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I-Peptides ePurity High Retatrutide 10mg yokunciphisa umzimba kunye nesifo seswekile
Ubunyulu: >99%
Ilizwe: I-Lyophilized Powder
Imbonakalo: Umgubo omhlophe
Inkcazo: 5mg/10mg/15mg/20mg/30mg
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Retatrutide
I-Retaglutide yinto entsha ye-dipeptidyl peptidase-4 (DPP-4) inhibitor yeklasi ye-hypoglycemic drug enokuthintela ukuthotywa kwe-glucagon-like peptide-1 (GLP-1) kunye ne-glucose-exhomekeke kwi-insulin-ekhulula i-polypeptide (GIP) nge-DPP-4 i-enzyme emathunjini kunye negazi, apho ichaphazela i-insulin eyimfihlo ngokwandisa umsebenzi wabo we-pancreatic, ukwandisa umsebenzi wabo we-insulin. inqanaba lesiseko le-insulin yokuzila, ngelixa linciphisa ukukhuselwa kweglucagon ngamaseli e-pancreatic α, ngaloo ndlela ilawula ngokufanelekileyo iswekile yegazi emva kokutya. Isebenza kakuhle ngokubhekiselele kwimpembelelo ye-hypoglycemic, ukunyamezela, kunye nokuthotyelwa.
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I-Inclisiran sodium
I-Inclisiran sodium API (i-Active Pharmaceutical Ingredient) ifundwa ngokuyinhloko kwintsimi ye-RNA interference (RNAi) kunye ne-cardiovascular therapeutics. Njenge-siRNA ephindwe kabini ejolise kwi-PCSK9 gene, isetyenziselwa uphando lwangaphambili kunye nophando lweklinikhi ukuvavanya izicwangciso zexesha elide zokuthulisa imfuza yokunciphisa i-LDL-C (i-low-density lipoprotein cholesterol). Ikwasebenza njengekhompawundi yemodeli yokuphanda ngeenkqubo zokuhanjiswa kwe-siRNA, uzinzo, kunye nonyango lwe-RNA olujoliswe esibindini.
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Fmoc-Gly-Gly-OH
I-Fmoc-Gly-Gly-OH yidipeptide esetyenziswa njengebhloko yokwakha esisiseko kwi-soli-phase peptide synthesis (SPPS). Ibonisa iintsalela ze-glycine ezimbini kunye ne-Fmoc-ekhuselweyo ye-N-terminus, evumela ukulawulwa kwekhonkco le-peptide. Ngenxa yobungakanani obuncinci be-glycine kunye nokuguquguquka, le dipeptide ihlala ifundwa kumxholo we-peptide backbone dynamics, uyilo lwekhonkco, kunye nemodeli yesakhiwo kwiipeptide kunye neeproteni.
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Fmoc-Thr(tBu)-Phe-OH
I-Fmoc-Thr(tBu)-Phe-OH yibhloko yokwakha yeedipeptide eqhele ukusetyenziswa kwi-soli-phase peptide synthesis (SPPS). Iqela le-Fmoc (i-9-fluorenylmethyloxycarbonyl) likhusela i-N-terminus, ngelixa iqela le-tBu (tert-butyl) likhusela i-hydroxyl side chain of threonine. Le dipeptide ikhuselweyo iphononongwa ngendima yayo ekuququzeleleni ulwalulo olululo lwepeptide, ukunciphisa iracemization, kunye nokwenza imodeli yemotifs yolandelelwano oluthile kulwakhiwo lweprotheyini kunye nezifundo zokusebenzisana.
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AEEA-AEEA
I-AEEA-AEEA yi-hydrophilic, i-flexible spacer edla ngokusetyenziswa kwi-peptide kunye nophando lokudibanisa iziyobisi. Iqukethe iiyunithi ezimbini ezisekelwe kwi-ethylene glycol, okwenza kube luncedo ekufundeni imiphumo ye-linker ubude kunye nokuguquguquka kwintsebenziswano ye-molecular, i-solubility, kunye nomsebenzi we-biological. Abaphandi bahlala besebenzisa iiyunithi ze-AEEA ukuvavanya ukuba i-spacers zinefuthe njani ekusebenzeni kwe-antibody-drug conjugates (ADCs), i-peptide-drug conjugates, kunye nezinye i-bioconjugates.
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![Fmoc-L-Lys[Eic(OtBu)-γ-Glu(OtBu)-AEEA]-OH](https://cdn.globalso.com/gentolexgroup/Glepaglutide10-300x300.png)
Fmoc-L-Lys[Eic(OtBu)-γ-Glu(OtBu)-AEEA]-OH
Le khompawundi lukhuselweyo, lusebenza ngokuphuma kwi-lysine esetyenziswa kwi-peptide synthesis kunye nophuhliso lwe-conjugate yeziyobisi. Ibonisa iqela le-Fmoc lokukhusela i-N-terminal, kunye nokuguqulwa kwe-side-chain kunye ne-Eic (OtBu) (i-eicosanoic acid derivative), i-γ-glutamic acid (γ-Glu), kunye ne-AEEA (aminoethoxyethoxyacetate). La macandelo enzelwe ukufunda iziphumo ze-lipidation, i-spacer chemistry, kunye nokukhutshwa kweziyobisi ezilawulwayo. Iphandwa ngokubanzi kumxholo wezicwangciso zeprodrug, i-ADC linkers, kunye ne-membrane-interacting peptides.
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![Fmoc-L-Lys[Ste(OtBu)-γ-Glu-(OtBu)-AEEA-AEEA]-OH](https://cdn.globalso.com/gentolexgroup/Glepaglutide9-300x300.png)
Fmoc-L-Lys[Ste(OtBu)-γ-Glu-(OtBu)-AEEA-AEEA]-OH
Le khompawundi yi-lysine derivative eguquliweyo esetyenziswa kwi-peptide synthesis, ngakumbi ekwakheni i-conjugates yepeptide ekujoliswe kuyo okanye esebenzayo. Iqela le-Fmoc livumela ukuhlanganiswa kwe-stepwise nge-Fmoc solid-phase peptide synthesis (SPPS). Ikhonkco elisecaleni liguqulwa kunye ne-stearic acid derivative (Ste), γ-glutamic acid (γ-Glu), kunye ne-AEEA (aminoethoxyethoxyacetate) ezimbini zokudibanisa, ezibonelela nge-hydrophobicity, iipropati zentlawulo, kunye ne-flexible spacing. Iqhele ukufundwa ngendima yayo kwiinkqubo zokuhanjiswa kweziyobisi, kubandakanywa i-antibody-drug conjugates (ADCs) kunye neepeptides ezingena kwiseli.
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I-Liraglutide ye-Anti-Diabetics yoLawulo lweSwekile yeGazi CAS NO.204656-20-2
Isithako esisebenzayo:I-Liraglutide (i-analog ye-glucagon-like peptide-1 (GLP-1) eveliswe yigwele ngetekhnoloji yokuhlanganiswa kwakhona kofuzo).
Igama leMchiza:Arg34Lys26-(N-e-(γ-Glu(N-α-hexadecanoyl)))-GLP-1[7-37]
Ezinye izithako:I-Disodium Hydrogen Phosphate Dihydrate, iPropylene Glycol, i-Hydrochloric Acid kunye / okanye i-Sodium Hydroxide (njenge-pH Adjusters Kuphela), i-Phenol, kunye naManzi okuTofa.
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I-Leuprorelin Acetate ilawula iSecretion of Gonadal Hormones
Igama: Leuprorelin
Inombolo ye-CAS: 53714-56-0
Ifomula yemolekyuli: C59H84N16O12
Ubunzima bemolekyuli: 1209.4
Inombolo ye-EINECS: 633-395-9
Ukujikeleza okuthe ngqo: D25 -31.7 ° (c = 1 kwi-1% i-acetic acid)
Ubuninzi: 1.44±0.1 g/cm3(Kuqikelelwe)
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Boc-His(Trt)-Aib-Gln(Trt)-Gly-OH
Boc-His(Trt)-Aib-Gln(Trt)-Gly-OHyitetrapeptide ekhuselweyo esetyenziswa kwi-peptide synthesis kunye nezifundo zesakhiwo. Iqela le-Boc (tert-butyloxycarbonyl) likhusela i-N-terminus, ngelixa amaqela e-Trt (trityl) akhusela amatyathanga asecaleni e-histidine kunye ne-glutamine ukukhusela ukuphendula okungafunwayo. Ubukho be-Aib (α-aminoisobutyric acid) bukhuthaza ukuhambelana kwe-helical kunye nokuphucula ukuzinza kwe-peptide. Le peptide ixabisekile ekuphandeni ukusonga iipeptide, uzinzo, nanjengesikafula ukuyila iipeptides ezisebenza ngokwebhayoloji.
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I-BPC-157
I-BPC-157 API isebenzisa inkqubo yesigaba esiqinileyo (SPPS):
Ukucoceka okuphezulu: ≥99% (ukuchongwa kwe-HPLC)
Intsalela ephantsi yokungcola, akukho endotoxin, akukho ngcoliseko yentsimbi enzima
Uzinzo lwebhetshi, ukuphinda-phinda okunamandla, inkxaso yokusetyenziswa kwenqanaba lokutofa
Inkxaso yobonelelo ngegram kunye nekhilogram ukukhawulelana neemfuno zamanqanaba ahlukeneyo ukusuka kwiR&D ukuya kushishino.