Iimveliso
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Ste-γ-Glu-AEEA-AEEA-OSU
I-Ste-γ-Glu-AEEA-AEEA-OSU yi-synthetic lipidated linker molecule eyenzelwe ukuhanjiswa kwechiza ekujoliswe kulo kunye ne-antibody-drug conjugates (ADCs). Ibonisa umsila we-stearoyl (Ste) we-hydrophobic, i-γ-glutamyl ejoliswe kuyo, i-AEEA spacers yokuguquguquka, kunye neqela le-OSu (NHS ester) lokudibanisa ngokufanelekileyo.
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Fmoc-Ile-αMeLeu-Leu-OH
I-Fmoc-Ile-αMeLeu-Leu-OH yibhloko yokwakha ekhuselweyo ye-tripeptide ene-α-methylated leucine, esetyenziswa ngokuqhelekileyo kwi-peptide yoyilo lweziyobisi ukuphucula ukuzinza kwe-metabolic kunye nokukhetha kwe-receptor.
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I-Dodecyl Phosphocholine (DPC)
I-Dodecyl Phosphocholine (DPC) sisicoci sokwenziwa se-zwitterionic esisetyenziswa kakhulu kuphando lweprotheyini yenwebu kunye nebhayoloji yolwakhiwo, ngakumbi kwi-NMR spectroscopy kunye necrystallography.
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I-N-Acetylneuraminic Acid(Neu5Ac Sialic Acid)
I-N-Acetylneuraminic Acid (Neu5Ac), eyaziwa ngokuba yi-asilic acid, yimonosaccharide eyenzeka ngokwemvelo ebandakanyeka kwimisebenzi ebalulekileyo yeselula kunye ne-immune. Idlala indima ephambili ekubonakalisweni kweeseli, ukukhusela i-pathogen, kunye nokuphuhliswa kwengqondo.
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Ergothioneine
I-Ergothioneine yi-amino acid-derived antioxidant evela ngokwemvelo, efundelwe amandla ayo anamandla e-cytoprotective kunye ne-anti-aging properties. Idityaniswe yifungi kunye neebhaktheriya kwaye iqokelele kwiithishu ezivezwe kuxinzelelo lwe-oxidative.
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NMN
Uphononongo lwangaphambi kweklinikhi kunye nolutsha lwangaphambili lucebisa i-NMN inokukhuthaza ubomi obude, ukunyamezela komzimba, kunye nokusebenza kwengqondo.
Iimpawu zeAPI:
Ukucoceka okuphezulu ≥99%
I-Pharmaceutical-grade, ilungele imixube yomlomo okanye etofwayo
Yenziwe phantsi kwemigangatho efana ne-GMP
I-NMN API ilungele ukusetyenziswa kwizongezelelo zokulwa nokuguga, unyango lwe-metabolic, kunye nophando lobomi obude.
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IGlucagon
IGlucagon yihomoni yendalo ye-peptide esetyenziswa njengonyango olungxamisekileyo kwi-hypoglycemia enzima kwaye ifundelwe indima yayo kulawulo lwe-metabolic, ukuncipha kobunzima, kunye noxilongo lokwetyisa.
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Motixafortide
I-Motixafortide yi-peptide yokwenziwa kwe-CXCR4 echasene ne-peptide ephuhliswe ukudibanisa iiseli ze-hematopoietic stem (HSCs) ukwenzela ukutshintshwa kwe-autologous kwaye iphinda ifundwe kwi-oncology kunye ne-immunotherapy.
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IGlepaglutide
I-Glepaglutide yi-analog ye-GLP-2 yexesha elide eyenzelwe unyango lwe-bowel syndrome (SBS). Yandisa ukufunxwa kwamathumbu kunye nokukhula, inceda izigulane ukunciphisa ukuxhomekeka kwisondlo sabazali.
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Elamipretide
I-Elamipretide yi-tetrapeptide ejoliswe kwi-mitochondria ephuhliswe ukunyanga izifo ezibangelwa ukungasebenzi kakuhle kwe-mitochondrial, kubandakanywa ne-myopathy ye-mitochondrial ephambili, i-Barth syndrome, kunye nokusilela kwentliziyo.
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I-Donidalorsen
I-Donidalorsen API yi-oligonucleotide ye-antisense (ASO) ephantsi kophando lonyango lwe-angioedema ye-hereditary (HAE) kunye neemeko ezinxulumene nokuvuvukala. Kufundwa kumxholo wonyango olujoliswe kwi-RNA, ejolise ekunciphiseni ukubonakaliswa kweplasma prekallikrein(KLKB1 mRNA). Abaphandi basebenzisa i-Donidalorsen ukuphonononga iindlela zokuthulisa imfuza, i-pharmacokinetics exhomekeke kwidosi, kunye nolawulo lwexesha elide lokudumba kwe-bradykinin-mediated.
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IFitusiran
I-Fitusiran API yi-RNA encinci ephazamisayo (i-siRNA) ephandwe ngokukodwa kwintsimi ye-hemophilia kunye nokuphazamiseka kwe-coagulation. Ijolise kwii-antithrombin (AT okanye i-SERPINC1)gene esibindini ukunciphisa imveliso ye-antithrombin. Abaphandi basebenzisa i-Fitusiran ukuphonononga iindlela zokuphazamiseka kwe-RNA (i-RNAi), ukuthuliswa kofuzo oluthile lwesibindi, kunye nezicwangciso zonyango ezinoveli zokubuyisela i-coagulation kwi-hemophilia A kunye ne-B izigulane, kunye okanye ngaphandle kwe-inhibitors.