Iimveliso
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Givosiran
I-Givosiran API yi-RNA encinci ephazamisayo (i-siRNA) efundela unyango lwe-acute hepatic porphyria (AHP). Ijolise ngokukodwa kwiI-ALAS1gene (i-aminolevulinic acid synthase 1), ebandakanyeka kwi-heme biosynthesis pathway. Abaphandi basebenzisa i-Givosiran ukuphanda ukungenelela kwe-RNA (RNAi)-based therapies, ukuthulisa i-gene ejoliswe kwisibindi, kunye nokuguqulwa kweendlela ze-metabolic ezibandakanyekayo kwi-porphyria kunye nokuphazamiseka kwemfuza okuhambelanayo.
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Pegcetacoplan
I-Pegcetacoplan yipeptide ye-pegylated cyclic esebenza njenge-C3 ejoliswe kwi-complement inhibitor, eyenzelwe unyango lwezifo ezincedisayo ezifana ne-paroxysmal nocturnal hemoglobinuria (PNH) kunye ne-geographic atrophy (GA) kwi-macular degeneration ehlobene neminyaka.
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Plozasiran
I-Plozasiran API yi-RNA encinci ephazamisayo (i-siRNA) ephuhliselwe unyango lwe-hypertriglyceridemia kunye ne-cardiovascular and metabolic disorders. Ijolise kwiAPOC3gene, efaka i-apolipoprotein C-III, umlawuli oyintloko we-triglyceride metabolism. Kuphando, i-Plozasiran isetyenziselwa ukufunda izicwangciso ze-RNAi-based based lipid-downing, i-gene-sincing specificity, kunye nonyango oluthatha ixesha elide kwiimeko ezifana ne-familial chylomicronemia syndrome (FCS) kunye ne-dyslipidemia edibeneyo.
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Zilebesiran
I-Zilebesiran API yi-RNA encinci ephazamisayo yophando (i-siRNA) ephuhliselwe unyango lwe-hypertension. Ijolise kwiAGTgene, efaka i-angiotensinogen-inxalenye ephambili yenkqubo ye-renin-angiotensin-aldosterone (RAAS). Kuphando, i-Zilebesiran isetyenziselwa ukufunda iindlela zokuthulisa i-gene yokulawula uxinzelelo lwegazi ixesha elide, iteknoloji yokuhambisa i-RNAi, kunye nendima ebanzi yendlela ye-RAAS kwi-cardiovascular and renal disease.
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Palopegteriparatide
I-Palopegteriparatide yi-hormone receptor agonist yexesha elide ye-parathyroid (PTH1R agonist), ephuhliswe unyango lwe-hypoparathyroidism engapheliyo. I-analog ye-pegylated ye-PTH (1-34) eyenzelwe ukubonelela ngolawulo lwe-calcium oluzinzileyo kunye ne-dosing kanye ngeveki.
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GHRP-6
I-GHRP-6 (i-Growth Hormone Releasing Peptide-6) yi-hexapeptide yokwenziwa esebenza njenge-hormone yokukhula secretagogue, ekhuthaza ukukhululwa kwemvelo kwe-hormone yokukhula (GH) ngokuvula i-GHSR-1a receptor.
Iimpawu zeAPI :
Ucoceko ≥99%
Yenziwe nge-soli-phase peptide synthesis (SPPS)
Inikezelwe kwi-R&D kunye nokusetyenziswa kwezorhwebo
I-GHRP-6 yi-peptide yophando eguquguqukayo yokuxhaswa kwe-metabolic, ukuvuselelwa kwemisipha, kunye nokuguqulwa kwehomoni.
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I-GHRP-2
I-GHRP-2 (i-Growth Hormone Releasing Peptide-2) yi-hexapeptide yokwenziwa kunye ne-hormone yokukhula enamandla secretagogue, eyenzelwe ukukhuthaza ukukhululwa kwendalo kwe-hormone yokukhula (GH) ngokuvula i-GHSR-1a i-receptor kwi-hypothalamus kunye ne-pituitary.
Iimpawu zeAPI:
Ucoceko ≥99%
Iyafumaneka kwi-R&D kunye nonikezelo lwentengiso, kunye namaxwebhu apheleleyo e-QC
I-GHRP-2 yi-peptide yophando oluxabisekileyo kwiinkalo ze-endocrinology, iyeza lokuvuselela, kunye nonyango olunxulumene neminyaka.
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Hexarelin
I-Hexarelin yi-hormone yokukhula eyenziwa yi-secretagogue peptide (GHS) kunye ne-GHSR-1a enamandla ye-agonist, ephuhliswe ukukhuthaza ukukhululwa kwehomoni engapheliyo (GH). Yeyosapho lwe-ghrelin mimetic kwaye yenziwe ngama-amino acids amathandathu (i-hexapeptide), enika uzinzo oluphuculweyo lwe-metabolic kunye neziphumo ezinamandla zokukhupha i-GH xa kuthelekiswa ne-analog yangaphambili efana ne-GHRP-6.
Iimpawu zeAPI :
Ubunyulu ≥ 99%
Iveliswe nge-soli-phase peptide synthesis (SPPS)
Imigangatho efana ne-GMP, i-endotoxin ephantsi kunye neentsalela ze-solvent
Unikezelo oluguquguqukayo: i-R&D ukuya kwisikali sorhwebo
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Melanotan II
Iimpawu zeAPI:
Ukucoceka okuphezulu ≥ 99%
Idityaniswe nge-soli-phase peptide synthesis (SPPS)
I-endotoxin ephantsi, izinyibilikisi ezishiyekileyo eziphantsi
Ifumaneka kwi-R&D ukuya kwisikali sorhwebo -
Imelanotan 1
I-Melanotan 1 API iveliswa kusetyenziswa iteknoloji yesigaba esiqinileyo se-peptide synthesis (SPPS) phantsi kweemeko ezingqongqo zokulawula umgangatho we-GMP.
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Ukucoceka okuphezulu ≥99%
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I-Solid-phase peptide synthesis (SPPS)
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Imigangatho yokuvelisa efana ne-GMP
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Amaxwebhu apheleleyo: COA, MSDS, idatha yokuzinza
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Ubonelelo olunokwehla: I-R&D ukuya kumanqanaba orhwebo
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I-MOTS-C
I-MOTS-C API iveliswa phantsi kweemeko ezingqongqo ezifana ne-GMP usebenzisa iteknoloji yesigaba esiqinileyo se-peptide synthesis (SPPS) ukuqinisekisa umgangatho wayo ophezulu, ukucoceka okuphezulu kunye nokuzinza okuphezulu kophando kunye nokusetyenziswa kwezonyango.
Iimpawu zeMveliso:Ubunyulu ≥ 99% (iqinisekiswe yi-HPLC kunye ne-LC-MS),
I-endotoxin ephantsi kunye nomxholo we-solvent eshiyekileyo,
Iveliswe ngokuhambelana ne-ICH Q7 kunye neeprothokholi ezifana ne-GMP,
Unokufezekisa imveliso enkulu, ukusuka kwi-milligram-level R & D batches ukuya kwi-gram-level kunye ne-kilogram-level unikezelo lwezorhwebo. -
Ipamorelin
I-Ipamorelin API ilungiselelwe ngumgangatho ophezulu ** inkqubo ye-peptide synthesis yesigaba esiqinileyo (SPPS) ** kwaye ihlanjululwe ngokungqongqo kunye novavanyo lomgangatho, olufanelekileyo ukusetyenziswa kwemibhobho kwangaphambili kuphando lwesayensi kunye nophuhliso kunye neenkampani zamachiza.
Iimpawu zemveliso ziquka:
Ubunyulu ≥99% (uvavanyo lweHPLC)
Ayikho i-endotoxin, i-solvent eshiyekileyo ephantsi, ukungcoliseka kwe-ion yentsimbi
Ukubonelela ngesethi epheleleyo yamaxwebhu asemgangathweni: i-COA, ingxelo yokufunda ukuzinza, uhlalutyo lwe-spectrum yokungcola, njl.
Customizable gram-level ~ kilogram-level unikezelo