I-REVERSE T3 ye-protein synthesis, i-thermoregulation, imveliso yamandla kunye nommiselo
Iinkcukacha zeMveliso
| Igama | BUYISA T3 |
| Inombolo yeCAS | 5817-39-0 |
| Ifomula yemolekyuli | I-C15H12I3NO4 |
| Ubunzima bemolekyuli | 650.97 |
| Indawo yokunyibilika | 234-238°C |
| Indawo yokubilisa | 534.6±50.0°C |
| Ubunyulu | 98% |
| Ugcino | Gcina kwindawo emnyama, itywinwe kwindawo eyomileyo, Gcina kwisikhenkcisi, ngaphantsi kwe-20°C |
| Ifom | Umgubo |
| Umbala | I-Beige ePale ukuya kuBrown |
| Ukupakisha | Ibhegi ye-PE + Ibhegi yeAluminiyam |
Izithethantonye
ReverseT3(3,3',5'-Triiodo-L-Thyronine);L-Tyrosine,O-(4-hydroxy-3,5-diiodophenyl)-3-iodo-;(2S) -2-aMino-3-[4-(4-hydroxy-3,5-diiodophe) noxy)-3-iodophenyl]propanoicacid;REVERSET3;T3;LIOTHYRONIN;L-3,3',5'-TRIIODOTHYRONINE;3,3′,5′-Triiodo-L-thyronine(ReverseT3) isisombululo
Isiphumo se-Pharmacological
Inkcazo
Idlala lengqula lelona dlala le-endocrine likhulu emzimbeni womntu, kwaye ezona zinto zisebenzayo zikhutshiweyo yi-tetraiodothyronine (T4) kunye ne-triiodothyronine (T3), ezibaluleke kakhulu kwi-protein synthesis, ukulawula ubushushu bomzimba, ukuveliswa kwamandla kunye nendima yokulawula. Uninzi lwe-T3 kwi-serum iguqulwa kwi-peripheral tissue deiodination, kwaye inxalenye encinci ye-T3 ifihliwe ngokuthe ngqo yi-thyroid kwaye ikhutshwe egazini. Uninzi lwe-T3 kwi-serum ibophelelwe kwiiprotheni ezibophelelayo, malunga ne-90% yazo ibophelelwe kwi-thyroxine-binding globulin (TBG), intsalela ibophelelwe kwi-albumin, kwaye ixabiso elincinci kakhulu libophelelwe kwi-prealbumin ye-thyroxine-binding (TBPA). Umxholo we-T3 kwi-serum ngu-1/80-1/50 we-T4, kodwa umsebenzi we-biological we-T3 ngamaxesha angama-5-10 we-T4. I-T3 idlala indima ebalulekileyo ekugwebeni imeko ye-physiological yomzimba womntu, ngoko kubaluleke kakhulu ukufumanisa umxholo we-T3 kwi-serum.
Ukubaluleka kweklinikhi
Ukuzimisela kwe-triiodothyronine sesinye sezibonakaliso ezibuthathaka zokuxilongwa kwe-hyperthyroidism. Xa i-hyperthyroidism isanda, ikwayi-precurrence yokuphindaphinda kwe-hyperthyroidism. Ukongeza, kuya kwanda ngexesha lokukhulelwa kunye ne-hepatitis enzima. I-Hypothyroidism, i-goiter elula, i-nephritis enzima kunye nengapheliyo, i-hepatitis engapheliyo, i-cirrhosis yesibindi iyancipha. Ugxininiso lwe-Serum T3 lubonisa umsebenzi we-thyroid gland kwizicubu ezijikelezileyo kunokuba i-secretory state ye-thyroid gland. Ukuzimisela kwe-T3 kungasetyenziselwa ukuxilongwa kwe-T3-hyperthyroidism, ukuchongwa kwe-hyperthyroidism yokuqala kunye nokuxilongwa kwe-pseudothyrotoxicosis. Inqanaba le-serum T3 lilonke lihambelana notshintsho lwenqanaba le-T4. Ingumqondiso obuthathaka wokuxilongwa komsebenzi we-thyroid, ngakumbi ukuxilongwa kwangaphambili. Luphawu oluthile lokuxilonga lwe-T3 hyperthyroidism, kodwa lunexabiso elincinci lokuxilongwa kwe-thyroid function. Kwizigulane eziphathwe ngamachiza e-thyroid, kufuneka zidibaniswe ne-thyroxine epheleleyo (TT4) kwaye, ukuba kuyimfuneko, i-thyrotropin (TSH) ngexesha elifanayo ukunceda ukugweba isimo sokusebenza kwe-thyroid.
