Ukubuyela umva kwi-T3 yePronthein Synthesis, umthendeleko, ukuveliswa kwamandla kunye nommiselo oboniswe umfanekiso

Ukubuyela umva kwi-T3 kwi-synthesis synthesis, umthendeleko, ukuveliswa kwamandla kunye nommiselo

Inkcazo emfutshane:

Inqaku lokunyibilika: 234-238 ° C (I-LAT.)

Inqaku lokubila: 534.6 ± 50.0 ° C (iqikelelwe)

Ukuxinana: 2.387 ± 0.06G / CM3 (iqikelelwe)

I-Flash Point: 9 ° C

Iimeko zokugcina: Gcina kwindawo emnyama, eselwandle, ivenkile kwi-freezer engaphantsi kwe-20 ° C

U-Solidality: DMSO (kancinci), i-methanol (kancinci)

I-Acidity Coanced: (pka) 2.17 ± 0.20 (iqikelelwe)

IFOMU: IPOLDER

Faka umbala: I-pale ye-pale to brown

Thumela i-imeyile kuthi

Iinkcukacha zemveliso

Iimpawu zeMveliso

Iinkcukacha zemveliso

Igama	Ukubuyela umva kwi-t3
Inombolo ye-CAS	I-5817-39-0-0
Ifomula yemolekyuli	C15h12i3NO4
Ubunzima bemolekyuli	I-650.97
Indawo yokunyibilika	234-238 ° C
Indawo yokubila	I-534.6 ± 50.0 ° C
Ubunyulu	I-98%
Ukugcinwa	Gcina indawo emnyama, etywiniweyo yomile, ivenkile e-freezer, i-4 ° C
Ifom	Umgubo
Umbala	I-pale ye-beige to brown
Ukupakisha	Ibhegi ye-PE + i-aluminium Bag

Izithethantonye

I-Revervet3 (3,3 ', 5'-i-triodio-l-i-gorosine); l [4- (4-hydroxy-3,5-i-i-i-i-i-i-riothylin] i-propanoicachid; -thronine (Reversela3) isisombululo

Isiphumo se-Pharmacociological

Inkcazo

I-Hidroid Gland yeyona gland yelona ntsimi likhulu emzimbeni womntu, kwaye ezona zinto ziphambili zikhutshiwe yiTetraidythorone (T4) kunye ne-Triodiolyeine (i-T4), iMigaqo yeGenoloji, iMveliso yeGolide, iMveliso yeGolide kunye neNdawo yeMveliso yeMibutho kunye neDilesi yeMveliso kunye neNdawo yeMveliso yeMihlaba. Uninzi lwe-T3 kwi-serm iguqulwe kwi-peripheral yezicubu, kwaye inxalenye encinci ye-T3 igcinwa ngokuthe ngqo yi-thysid kwaye ikhutshwe egazini. Uninzi lwe-T3 kwiSluum lubotshelela kwiiproteni, malunga neepesenti ezingama-90 ze-tendolin ebopha i-finbulin (i-TBG), ukubopha i-tbg) kwi-albhamulin, kwaye isixa esincinci kakhulu siboshwe kwi-Prealbumin (i-TB). Umxholo we-T3 kwiSluum yi-1 / 80-1 / 50 yeyo le-T4, kodwa umsebenzi webhayoloji ye-T3 ngamaxesha angama-5 ukuya kweli-5. I-T3 idlala indima ebalulekileyo ekugwebeni inqanaba lomzimba lomzimba womntu, ngenxa yoko ibaluleke kakhulu ekufumaneni umxholo we-T3 kwiSluum.

Ukubaluleka kweKlinikhi

Ukumiselwa kwe-triodioineron yenye yeezalathiso ezibuthathaka zokufumanisa i-hypernidism. Xa ihyperthyroidism yonyuka, ikwangumphambili wokuphinda kwenziwe i-hyperthyraidism. Ukongeza, iyakonyuka ngexesha lokukhulelwa kunye ne-hepatitis ye-hepatitis. I-hypothyroidism, iGoititer elula, elula nezingapheliyo, iHopatis engapheliyo, isifo se-Philhotisis, i-Peathotis yehle. I-Serum t3 uxinzelelo lubonisa umsebenzi we-Hidroid Gland kwizicubu ezijikelezileyo endaweni yemeko yenkxaso ye-thland. I-T3 Ukuzimisela kunokusetyenziselwa ukufunyaniswa kwe-T3-hypelosismidism yase-T3, ukuchongwa kwe-hyperthyroidism kunye nokuxilongwa kwe-pseudoudothyroosis. Inqanaba elipheleleyo le-SUM3 lihambelana ngokubanzi notshintsho lwe-T4. Yisalathi esibuthathaka sokufumanisa umsebenzi we-Hineroid, ngakumbi ukuxilongwa kwangoko. Isalathisi esithile sokuqonda isiqinisekiso se-T3 ye-hyperthyroidism, kodwa ingenaxabiso elincinci lokufumanisa umsebenzi we-Hineroid. Ukuze izigulana zinyangwe kunye neziyobisi ze-thyroid, kufuneka zidityaniswe ne-thyroxine iyonke (TT4) kwaye, ukuba kukho imfuneko, i-hidrotin (TSH) ngaxeshanye ukunceda ukugweba imeko yomsebenzi we-Hineroid.

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