Semaglutide
Semaglutide API
I-Semaglutide yi-synthetic ye-glucagon-efana ne-peptide-1 (GLP-1) ye-receptor agonist yokwenziwa, ephuhliswe kunyango lwe-2 yesifo sikashukela kunye nokukhuluphala. Ukuguqulwa ngokwesakhiwo ukuxhathisa ukuthotywa kwe-enzymatic kunye nokuphucula i-half-life, i-Semaglutide ivumela ukulungelelaniswa kwe-dosing kanye ngeveki, ukuphucula kakhulu ukuthotyelwa kwesigulane.
YethuSemaglutide APIiveliswa ngenkqubo yokwenziwa ngokupheleleyo, isusa imingcipheko eyayanyaniswa neenkqubo zokuchaza ngokwebhayoloji, ezifana neprotein yeseli ye-host okanye ungcoliseko lwe-DNA. Yonke inkqubo yokwenziwa kwemveliso iye yaphuhliswa kwaye yaqinisekiswa kwisikali sekhilogram, ihlangabezana neemfuno ezingqongqo zomgangatho ezichazwe kwi-FDA's 2021 isikhokelo malunga nokungeniswa kwe-ANDA kumachiza e-peptide okwenziwa acocekileyo.
Indlela yokwenza
I-Semaglutide ilinganisa i-GLP-1 yomntu, i-hormone ye-incretin edlala indima ebalulekileyo kwi-glucose metabolism. Isebenza ngeendlela ezininzi ze-synergistic:
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Ivuselela ukukhutshwa kwe-insulinngendlela exhomekeke kwi-glucose
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Inciphisa ukukhutshwa kweglucagon, ukunciphisa i-hepatic glucose output
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Ilibazisa ukukhupha isisu, ekhokelela ekuphuculeni ulawulo lwe-glycemic postprandial
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Yehlisa umdla wokutya kunye nokuthatha amandla, ukuxhasa ukulahleka kwesisindo
Iziphumo zoNyango
Izifundo ezininzi zeklinikhi (umzekelo, i-SUSTAIN kunye ne-STEP izilingo) zibonise ukuba i-Semaglutide:
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Ukunciphisa ngokuphawulekayo i-HbA1c kunye nokuzila ukutya kwe-plasma ye-glucose amanqanaba kwizigulane ze-2 zeswekile
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Ikhuthaza ukwehla okukhulu kunye nokugcinwa kobunzima kubantu abatyebe kakhulu okanye abatyebe kakhulu
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Inciphisa iimpawu zengozi ye-cardiovascular risk markers ezifana noxinzelelo lwegazi kunye nokuvuvukala
Ngeprofayili ekhuselekileyo yokhuseleko kunye neenzuzo ezibanzi ze-metabolic, i-Semaglutide iye yaba yinto yokuqala ye-GLP-1 RA kwisifo seswekile kunye nonyango oluchasene nokutyeba. Inguqulo yethu ye-API igcina ukuthembeka okuphezulu kwesakhiwo kunye namanqanaba aphantsi okungcola (≤0.1% ukungcola okungaziwayo yi-HPLC), ukuqinisekisa ukuhambelana okugqwesileyo kwe-pharmacological.
