I-Tadalafil 171596-29-5 ukuya kunyanga ukungasebenzi kakuhle kwamadoda

I-Tadalafil (Tadalafil, Tadalafil) inefomula yemolekyuli ye-C22H19N3O4O4O4O4O kunye nobunzima bemolekyuli ye-389.4. Isetyenziswe ngokubanzi kunyango lwe-nearile eyindoda isusela ngo-2003, kunye negama lokurhweba i-cialis (Cialis). NgoJuni ka-2009, i-FDA ivumile i-Tadalafil eUnited States kunyango lwezigulana ezinehyperterial adperterest (pah) phantsi kwegama lokurhweba le-Adcirca. I-Tadalafil yaziswa ngo-2003 njengechiza kunyango lwe-ed. Kuthatha isiphumo imizuzu engama-30 emva kolawulo, kodwa eyona mpembelelo yi-2h emva kokuqala kwesenzo, kwaye ifuthe lingachaphazeleka kukutya. Idosi ye-Tadalafil yi-10 okanye i-20 mg, idosi yokuqala ye-10 mg, kwaye idosi ilungiswe ngokwempendulo yesigulana kunye nokuphendula okuchaseneyo. Izifundo zangaphambi kwentengiso zibonise ukuba emva kolawulo lomlomo olu-10 okanye i-20 mg ye-Tadalafil kwiiveki ezili-12, amaxabiso asebenzayo angama-67% kunye ne-81%, ngokulandelelana. Izifundo ezininzi zibonise ukuba i-Tadalafil inobuchule obungcono kunyango lwe-ed.

I-ERTEATLEGLERGY: I-TADALAFIL i-phosphodimerase yohlobo lwesi-5. Phantsi kwesenzo sokukhuthaza ngokwesondo, i-nitric ox synthase (i-iscic) kwi-Penile ye-Penile New-Endothelial Endotheliatial I-Syntyes ye-Nitric Oxide (HAYI) kwi-l-ringinine ye-wiric. AKUKHO BUNGOZIWEYO I-CYCCLASE I-Tuanososine Tuarhosphate ye-Cyclic Guanophote (CGMP), ngenxa yokwehla kwi-Cyclin Guanophote ye-Cyclin Guanosphate ye-Cyclin Guanophote ye-Cyclin Guanosphate ye-Corcles, ebangela ukuphumla okugudileyo umsipha. Uhlobo lwePhosphodiesterase Tep 5 (i-PD5) ihlazo kwimveliso engasebenziyo, yenza ipenisi ibe yindawo ebuthathaka. I-Tadalafil inika ukonakaliswa kwe-PDE5, ekhokelela ekuqokeleleni i-CGMP, ehlaziya umsipha ogudileyo we-Corpus Covernosum, ekhokelela kulwakhiwo lweNtlanganiso. Kuba i-nitrates ayingabo abanikeli, ukusetyenziswa kwe-Tadalafil kuya kukhulisa kakhulu inqanaba le-CGMM kwaye kukhokelele kwi-hypoteren enzima. Ke ngoko, ukusetyenziswa kwezibini ezidibeneyo kuchasene nokuziqhelanisa neklinikhi.

I-Tadalafil isebenza ngokuthintela ii-PEDs. I-GMP ihlazekile, ke ukusetyenziswa okuhlanganisiweyo kunye ne-niite kunokubangela ukuhla kwegazi kuxinzelelo lwegazi kwaye kwandise umngcipheko we-syncope. I-CY3PA4 ARDCKIS iya kunciphisa i-bioaanafil, kunye nomdibaniso we-rifampicin, i-cimithidin, i-erythromycin, i-clorithromycin, i-itraconcin, i-itraconcin, i-ITVE ye-ITVE i-ITV inokuthi ilungiswe. Ukuza kuthi ga ngoku, akukho ngxelo zokuba iiparamitha ze-phammacokinic zale mveliso ziyachaphazeleka kukutya kunye notywala.