I-tianeptine yenkqubo ye-5-ht, i-sedation, i-anti-acetylcholine kunye nentliziyo yoxinzelelo
Iinkcukacha zemveliso
| Igama | Tianeptine |
| Inombolo ye-CAS | 1224690-84-9 |
| Ifomula yemolekyuli | C21h27cln2o8s2 |
| Ubunzima bemolekyuli | I-535.02 |
| Indawo yokunyibilika | 129-13 ° C |
| Indawo yokubila | I-609.2ºc nge-760 mmhg |
| Ubunyulu | I-99% |
| Ukugcinwa | Itywinwe kubushushu bomileyo, igumbi |
| Ifom | Umgubo |
| Umbala | Mhlophe |
| Ukupakisha | Ibhegi ye-PE + i-aluminium Bag |
Izithethantonye
Thm; tianeneptine -aulfmonononononorrate (THM); ITianetptineEulfaulfYoul; ITiianePulPulPulPulPulDononononononoul / TianePultinter
Isiphumo se-Pharmacociological
Isiphumo se-Pharmacociological
I-1. Indlela yokulwa i-antidepress yale mveliso yahlukile kule ye-TCA yendabuko. Inokonyusa i-puttake ye-5-ht kwi-synaptic cleft, kodwa inefuthe elibuthathaka kwi-5-ht ne na. Inokuba nefuthe lokwandisa usulelo olu-5-ht neuranial. Ayinabubi bemihlayizana, H1, α1 kunye ne-α2-natoli.
2. Ukusebenza kakuhle kwemveliso yale mveliso kuyafana ne-TCA, kunye nokhuseleko lwayo kunye nokukhohlakala kungcono kune-TCA (i-tricycticlides). Ukusebenza kwale mveliso kuyafana ne-SSRI Fluoxetine.
3. Uvavanyo lweziyobisi lwezilwanyana lubonise ukuba: luyanyusa umsebenzi owaziwayo weeseli zepiramidal kwimvubu enkulu kwaye ikhawuleze iphinde ibuyiselwe kwakhona kwi-infinity; Yandisa ukuphinda kwenziwe kwakhona kwe-5-hydroxytrypypypypypypypypypypy nge-neurons kwi-Cestbral Cortex kunye neHippocampus.
UPhando lweToolotyOlogy
-Ukuba, i-suble kunye neemvavanyo zexabiso zexabiso zebhayiloji, akukho msebenzi webhayoloji, umsebenzi we-PELR, i-atholotom anatomy.
- Uvavanyo lwetyhefu lokuzala kunye ne-teratogenicity: UTianegetity akanasiphumo kubuchule bokuzala babazali abanyangeleyo kunye nakuhlobo kunye nembewu.
Uvavanyo lwe-mutagenicity: UTianeptilo akanayo impembelelo.
Imiphumela
-Iintlungu ze-Epigastiric, iintlungu zesisu, umlomo owomileyo, i-Anorexia, iNatenasa, ukugabha, ukuqunjelwa;
-Unsomiyania, ukozela, ubusuku, ubuthathaka;
- TachyCardia, ongezelelweyo okuphezulu, iintlungu zenkonzo kwangaphambili;
-intloko, intloko ebuhlungu, etyhafisa, iyangcangcazela bubuso;
- Ukuphefumla, imvakalelo yokuxinana emqaleni;
- I-MyAlgia, iintlungu zangasemva, njl.
