I-tirzepatide yinoveli, i-Glucose-exhomekeke kwi-GluCoTROOTROPROPIC ye-InsepePic Polypeptide (GIP) kunye neGlucagon-i-Glucagon-1 (GLP-1) Anptor. Imele ukuqhubela phambili kunyango kunyango lwe-Diabetes 2 yeswekile kwaye ibonakalisile iziphumo ezithembisayo kulawulo lwezimba. I-Tirzpatide inaliti inja yifom yamayeza esetyenziselwa ukulungiselela isisombululo solawulo olungenamhlaba.
Indlela yesenzo
I-tirzpatide isebenza ngokuqhuba zombini i-GIP kunye ne-GLP-1 ReadPtors, ezibandakanyekileyo ekulawuleni amanqanaba eswekile yegazi kunye nomdla. I-Agonism yesibini ibonelela ngeziphumo ezininzi ezifanelekileyo:
I-Insulin ye-Insulin ephuculweyo: ivuselela ukukhutshwa kwe-insulin ngendlela enokuxhomekeka kweglucose, encedisa ekwenzeni amanqanaba eswekile yegazi ngaphandle kokubangela i-hypoglycemia.
Ukucinezelwa kweGlucagon I-Glucagon I-GLucagon yeGlucagon, i-hormone ephakamisa amanqanaba eswekile yegazi.
Ummiselo wokutya ongumdla: Ikhuthaza ukuxhalaba nokunciphisa ukutya, igalelo kwilahleko yobunzima.
I-Gastric Eckric Eckting: Ilibazisa ukuthotywa kwesisu, esinceda ekulawuleni iswekile yegazi yegazi.
UKUSETYENZISWA KOMSEBENZI
Malunga nohlaziyo lwamva nje, iTirzepatide ivunyiwe ngabasemagunyeni abalawulayo njengolawulo lwe-US kunye nolawulo lweziyobisi (i-FDA) ngonyango lwesifo seswekile 2. Ikwaphantsi kophando malunga nokusetyenziswa kwayo kulawulo olukhulayo.
Izibonelelo
Ulawulo olusebenzayo lwe-Glycemic: Ukuncitshiswa okukhulu kwamanqanaba e-HBA1C.
Ukuphulukana nobunzima: Ukuncitshiswa kobunzima obukhulu, okuyingenelo kwizigulana ezinesifo seswekile 2 seswekile kunye nokutyeba kakhulu.
Izibonelelo zentliziyo:
Ukulula: I-doy-veki nganye iphucula ukubambelela kubaguli xa kuthelekiswa namayeza emihla ngemihla.
Iziphumo ezinokubakho
Ngelixa iTirzepatide inyamezele kakuhle, abanye abasebenzisi banokufumana iziphumo ebezingalindelekanga, kubandakanya:
Imicimbi yeJastrointentinal:
Isicaphucaphu, ukugabha, urhudo kunye nokuqunjelwa kuqhelekile, ngakumbi ngamanqanaba okuqala kunyango.
Umngcipheko we-hypoglycemia: ngakumbi xa isetyenziswa ngokudibeneyo kunye namanye amayeza aphantsi kweglucose.
I-pancreatitis: inqabile kodwa imbi, ifuna ukuba kuthathelwe ingqalelo kwangoko ukuba iimpawu zifana nentlungu enzima yesisu.
Ukulungiswa kunye nolawulo
Inja ye-tirzetide inaliti kufuneka iphinde iphinde iphinde iphinde inyibilikiswe i-Solvent efanelekileyo (ihlala inikezelwa kwikhithi) yokwenza isisombululo senaliti. Isisombululo esikhanyisiweyo ngokutsha kufuneka sicace kwaye simahla amasuntswana. Ilawulwa ngenkani esiswini, ithanga, okanye ingalo ephezulu.