I-Tirzepatide iyinoveli, i-glucose exhomekeke kwi-insulinotropic polypeptide (GIP) kunye ne-glucagon-like peptide-1 (GLP-1) receptor agonist. Imele ukuqhubela phambili okuphawulekayo kunyango lwe-2 yeswekile kwaye ibonise iziphumo ezithembisayo ekulawuleni ubunzima. I-Tirzepatide i-injection powder yifom ye-pharmaceutical esetyenziselwa ukulungisa isisombululo sokulawulwa kwe-subcutaneous.
Indlela yokwenza
I-Tirzepatide isebenza ngokuvula zombini i-GIP kunye ne-GLP-1 receptors, ezibandakanyekayo ekulawuleni amanqanaba eswekile yegazi kunye nomdla wokutya. I-agonism emibini ibonelela ngeziphumo ezininzi eziluncedo:
I-Insulin Secretion eyandisiweyo: Ivuselela ukukhululwa kwe-insulin ngendlela exhomekeke kwi-glucose, inceda ukunciphisa amanqanaba eswekile yegazi ngaphandle kokubangela i-hypoglycemia.
Ukukhutshwa kweGlucagon ecinezelweyo: Yehlisa ukukhutshwa kweglucagon, ihomoni ephakamisa amanqanaba eswekile yegazi.
I-Appetite Regulation: Ikhuthaza ukuhlutha kunye nokunciphisa ukutya, okunegalelo ekulahlekeni kwesisindo.
I-Slowed Gastric Emptying: Ilibazisa ukuphuma kwesisu, enceda ekulawuleni i-postprandial sugar spikes.
Usetyenziso oluvunyiweyo
Njengohlaziyo lwamva nje, i-Tirzepatide ivunyiwe ngabasemagunyeni abalawulayo njenge-US Food and Drug Administration (FDA) kunyango lwe-2 yeswekile. Ikwaphantsi kophando malunga nokusetyenziswa kwayo ekulawuleni ukutyeba.
Iingenelo
Ulawulo lweGlycemic olusebenzayo: Ukuncipha okubonakalayo kumanqanaba e-HbA1c.
Ukunciphisa Ubunzima: Ukunciphisa ubunzima obuninzi, obuluncedo kwizigulane ezinesifo seswekile se-2 kunye nokukhuluphala.
I-Cardiovascular Benefits: Ukuphuculwa okunokwenzeka kwimiba yengozi ye-cardiovascular risk, nangona izifundo eziqhubekayo zivavanya ngakumbi lo mba.
Uncedo: I-dosing kanye ngeveki iphucula ukuthotyelwa kwesigulane xa kuthelekiswa namayeza emihla ngemihla.
Iimpembelelo ezinokuba khona
Ngelixa iTirzepatide inyamezeleka kakuhle, abanye abasebenzisi banokufumana iziphumo ezibi, kubandakanya:
Imiba yeGastrointestinal:
Isicaphucaphu, ukuhlanza, isifo sohudo, kunye nokuqunjelwa zixhaphakile, ngakumbi ngezigaba zokuqala zonyango.
Umngcipheko we-Hypoglycemia: Ingakumbi xa isetyenziswe ngokudibeneyo namanye amayeza okwehlisa i-glucose.
I-Pancreatitis: Inqabile kodwa inzulu, ifuna ukhathalelo lwezonyango olukhawulezileyo ukuba kukho iimpawu ezinjengeentlungu zesisu eziqatha.
Ukulungiselela noLawulo
I-Tirzepatide injection powder kufuneka ihlaziywe kunye ne-solvent efanelekileyo (ngokuqhelekileyo inikezelwa kwikiti) ukwenza isisombululo sokujova. Isisombululo esihlaziyiweyo kufuneka sicace kwaye singabi namacandelo. Ilawulwa ngaphantsi kwe-subcutaneously kwisisu, ithanga, okanye ingalo ephezulu.