Zilebesiran

Zilebesiran (API)

Isicelo soPhando:
I-Zilebesiran API yi-RNA encinci ephazamisayo yophando (i-siRNA) ephuhliselwe unyango lwe-hypertension. Ijolise kwiAGTgene, efaka i-angiotensinogen-inxalenye ephambili yenkqubo ye-renin-angiotensin-aldosterone (RAAS). Kuphando, i-Zilebesiran isetyenziselwa ukufunda iindlela zokuthulisa i-gene yokulawula uxinzelelo lwegazi ixesha elide, iteknoloji yokuhambisa i-RNAi, kunye nendima ebanzi yendlela ye-RAAS kwi-cardiovascular and renal disease.

Umsebenzi:
Zilebesiran imisebenzi ngokuthulaAGTi-mRNA esibindini, ekhokelela ekunciphiseni imveliso ye-angiotensinogen. Oku kukhokelela ekunciphiseni okusezantsi kumanqanaba e-angiotensin II, kunceda ukunciphisa uxinzelelo lwegazi ngendlela eqhubekayo. Njenge-API, i-Zilebesiran yenza ukuba kuphuhliswe unyango lwexesha elide, olungaphantsi kwe-antihypertensive olunokubakho kwi-dosing yekota okanye ye-biannual, enikezela ukuthotyelwa okuphuculweyo kunye nokulawula uxinzelelo lwegazi.