Boc-His(Trt)-Aib-Gln(Trt)-Gly-OH

Boc-His(Trt)-Aib-Gln(Trt)-Gly-OH

Isicelo soPhando:
Le tetrapeptide ekhuselweyo isetyenziswa kwi-peptide synthesis kunye nezifundo ezihambelanayo. Ukudityaniswa kwe-Aib (α-aminoisobutyric acid) kuvumela abaphandi ukuba baphande izakhiwo ze-helical kunye nokuziphatha kokusonga kwiipeptides ezimfutshane. Amaqela asebenzayo akhuselweyo (Boc, Trt) aqinisekisa ukuzinza kunye nokukhetha ngexesha le-peptide synthesis yesigaba esiqinileyo, okwenza kube yimodeli ebalulekileyo yokufunda i-peptide backbone dynamics kunye ne-side-chain interactions.

Umsebenzi:
I-Boc-His(Trt)-Aib-Gln(Trt)-Gly-OH isebenza njengekhompawundi yemodeli yokuhlola ukuzinza kwe-peptide kunye ne-structural motifs. I-Aib inegalelo ekuzinziseni kwe-helical, ngelixa i-histidine kunye ne-glutamine i-residues zibonelela ngeendawo ezinokusebenzisana ezinokubakho, eziluncedo ekuyileni i-peptides ye-bioactive okanye ukulinganisa amaqhekeza eprotheni. Inokuthi ibe yi-precursor yeepeptides ezisebenzayo kuphuhliso lwamachiza okanye uvavanyo lwe-biochemical.