I-Daptomycin 103060-53-3 yeZifo ezosulelayo
Iinkcukacha zeMveliso
| Igama | Daptomycin |
| inombolo yeCAS | 103060-53-3 |
| Ifomula yemolekyuli | I-C72H101N17O26 |
| Ubunzima bemolekyuli | 1620.67 |
| Inombolo ye-EINECS | 600-389-2 |
| Indawo yokunyibilika | 202-204°C |
| Indawo yokubilisa | 2078.2±65.0 °C (Kuxelwe kwangaphambili) |
| Ukuxinana | 1.45±0.1 g/cm3(Kuxelwe kwangaphambili) |
| Indawo yokuflasha | 87℃ |
| Iimeko zokugcina | Itywinwe kwindawo eyomileyo, Gcina kwisikhenkcisi, ngaphantsi kwe -20°C |
| Ukunyibilika | I-Methanol:i-soluble5mg/mL |
| I-acidity coefficient | (pKa) 4.00±0.10 (Kuxelwe kwangaphambili) |
| Ifomu | umgubo |
| Umbala | engenambala ukuya kumthubi |
Izithethantonye
N-[N-(1-Oxodecyl)-L-Trp-D-Asn-L-Asp-]-cyclo[L-Thr*-Gly-L-Orn-L-Asp-D-Ala-L-Asp- I-Gly-D-Ser-[(3R)-3-methyl-L-Glu-]-4-(2-aminophenyl)-4-oxo-L-Abu-];N-[N-Decanoyl-L-Trp- D-Asn-L-Asp-]-cyclo[Thr*-Gly-L-Orn-L-Asp-D-Ala-L-Asp-Gly-D-Ser-[(3R)-3-methyl-L- Glu-]-3-(2-aminobenzoyl)-L-Ala-];N-(1-Oxodecyl)-L-tryptophyl-D-asparaginyl-L-α-aspartyl-L-threonylglycyl-L-ornithinyl-L- α-aspartyl-D-alanyl-L-α-aspartylglycyl-D-seryl-(3R)-3-methyl-L-α-glutamyl-α,2-diamino-γ-oxo-benzenebutanoicacid (13-4)lactone; DAPTOMYCINE;Dapcin;Daptomycin,>=99%;DaptomycinReadyMadeSolution;Daptomycin(LY146032)
Inkcazo
I-antibiotic daptomycin yi-antibiotic ye-cyclic lipopeptide enesakhiwo esitsha esithathwe kumhluzi wokuvundiswa kwe-Streptomyces (S. reseosporus), ethintela i-biosynthesis ye-bacterial cell wall peptidoglycan ngokuphazamisa ukuthuthwa kwe-amino acids kwi-membrane yeseli.Ukutshintsha iimpawu ze-membrane ye-cytoplasmic kunokuphazamisa umsebenzi we-membrane yebhaktheriya ngeendlela ezininzi kwaye ubulale ngokukhawuleza ibhaktheriya ye-Gram-positive.Ukongeza kwisakhono sayo sokusebenza kwiibhaktheriya zeGram-positive, i-daptomycin ibaluleke kakhulu kwiintlobo ezizimeleyo ezibonise ukuxhathisa i-methicillin, i-vancomycin, kunye ne-linezolid in vitro.Inomsebenzi onamandla, kwaye le propati ineempembelelo zeklinikhi ezibaluleke kakhulu kwizigulana ezigula kakhulu.I-Eosinophilic pneumonia sisifo esinqabileyo kwaye esibi kakhulu sineempawu ezibandakanya umkhuhlane, ukukhohlela, ukuphefumla nzima, kunye nobunzima bokuphefumla.
Impembelelo ye-Antibacterial
I-Daptomycin inomsebenzi olungileyo we-bacteriostatic ngokuchasene neebhaktheriya ezahlukeneyo zokulwa namagciwane, njenge-MIC=0.06-0.5 μg/ml ye-methicillin-resistant Staphylococcus aureus (MRSA), kunye ne-methicillin-resistant Staphylococcus aureus (MRSA).I-MIC=0.0625～1μg/ml yebhaktheriya, i-MIC=0.12～0.5μg/ml ye-oxacillin-resistant Staphylococcus epidermidis, MIC=2.5μg/ml ye-enterococcus exhathisa kakhulu kwi-aminoglycoside antibiotics, i-MICmlBI ye-GICm2 ye-GICm2. ye-Enterococcus yi-0.5～1μg/ml, kwaye i-MIC ye-Enterococcus echasene ne-glycopeptide antibiotics yi-1～2μg/ml.
