I-Caspofungin ye-Antifungal Infections
Iinkcukacha zeMveliso
| Igama | Caspofungin |
| inombolo yeCAS | 162808-62-0 |
| Ifomula yemolekyuli | I-C52H88N10O15 |
| Ubunzima bemolekyuli | 1093.31 |
| Inombolo ye-EINECS | 1806241-263-5 |
| Indawo yokubilisa | 1408.1±65.0 °C (Kuxelwe kwangaphambili) |
| Ukuxinana | 1.36±0.1 g/cm3(Kuxelwe kwangaphambili) |
| I-acidity coefficient | (pKa) 9.86±0.26 (Kuxelwe kwangaphambili) |
Izithethantonye
CS-1171;Caspofungine;CASPOFUNGIN;CASPORFUNGIN;PneuMocandinB0,1-[(4R,5S)-5-[(2-aMinoethyl)aMino]-N2-(10,12-diMethyl-1-oxotetradecyl)-4-hydroxy- L-ornithine]-5-[(3R)-3-hydroxy-L-ornithine]-;CaspofunginMK-0991;Aids058650;Aids-058650
Iipropati zeMichiza
I-Caspofungin yayiyeyokuqala i-echinocandin evunyiweyo kunyango lwe-invasive fungal infections.Uvavanyo lwe-in vitro kunye ne-vivo luqinisekisile ukuba i-caspofungin inomsebenzi olungileyo wokulwa ne-antibacterial ngokuchasene ne-athogens ebalulekileyo engenelelayo-Candida kunye ne-Aspergillus.I-Caspofungin inokukrazula udonga lweseli ngokuthintela ukuhlanganiswa kwe-1,3-β-glucan.Ngokonyango, i-caspofungin inefuthe elihle kunyango lwe-candidiasis eyahlukeneyo kunye ne-aspergillosis.
Isiphumo
(1,3) -D-glucan synthase yinxalenye ephambili ye-fungal cell wall synthesis, kunye ne-caspofungin inokusebenzisa umphumo we-antifungal ngokungakhuphisani ngokuthintela le enzyme.Emva kokulawulwa kwe-intravenous, i-plasma yoxinaniso lwechiza lwehla ngokukhawuleza ngenxa yokusasazwa kwezicubu, kulandelwa kukukhululwa ngokuthe ngcembe kwechiza kwithishu.I-Metabolism ye-caspofungin yonyuka ngokunyuka kwedosi kwaye yayinxulumene nedosi ngexesha lokuzinza kunye needosi ezininzi.Ngoko ke, ukuze ufezekise amanqanaba onyango asebenzayo kwaye ugweme ukuqokelela kweziyobisi, umthamo wokuqala wokulayisha kufuneka ulawulwe kulandelwa idosi yokugcina.Xa usebenzisa i-cytochrome p4503A4 inducers ngexesha elifanayo, njenge-rifampicin, i-carbamazepine, i-dexamethasone, i-phenytoin, njl., Kucetyiswa ukuba ukwandise umthamo wokugcinwa kwe-caspofungin.
Iimpawu
Izibonakaliso ezivunyiweyo ze-FDA ze-caspofungin ziquka: 1. Umkhuhlane kunye ne-neutropenia: ichazwa njenge: fever>38 ° C kunye ne-absolute neutrophil count (ANC) ≤500 / ml, okanye nge-ANC ≤1000 / ml kwaye kuqikelelwa ukuba ingancitshiswa. ukuya ngaphantsi kwe-500/ml.Ngokwengcebiso ye-Infectious Diseases Society of America (IDSA), nangona izigulane ezinomkhuhlane oqhubekayo kunye ne-neutropenia ziye zanyangwa nge-antibiotics ebanzi, izigulane ezisemngciphekweni omkhulu zisacetyiswa ukuba zisebenzise unyango lwe-empiric antifungal, kuquka i-caspofungin kunye namanye amachiza e-antifungal. ..2. I-candidiasis ehlaselayo: I-IDSA incoma i-echinocandins (efana ne-caspofungin) njengeyeza elikhethiweyo kwi-candidemia.Ingasetyenziselwa ukunyanga amathumba angaphakathi kwesisu, i-peritonitis kunye nosulelo lwesifuba olubangelwa lusulelo lweCandida.3. I-candidiasis ye-Esophageal: I-Caspofungin ingasetyenziselwa ukunyanga i-candidiasis ye-esophageal kwizigulane ezine-refractory okanye ukunyamezela kwezinye iindlela zonyango.Uphononongo oluninzi lufumene ukuba isiphumo sonyango se-caspofungin sinokuthelekiswa ne-fluconazole.4. I-aspergillosis ehlaselayo: I-Caspofungin ivunyiwe kunyango lwe-aspergillosis ephazamisayo kwizigulane ezinokunyamezela, ukuchasana, kunye nokungasebenzi kweyeza eliphambili le-antifungal, i-voriconazole.Nangona kunjalo, i-echinocandin ayikhuthazwa njengonyango lokuqala.
