I-BPC-157

BPC-157 API

I-BPC-157 (igama elipheleleyo: i-Body Protection Compound 157) yi-peptide emfutshane eyenziwe nge-15 amino acids, ephuma kulandelelwano lweeprotheni ezikhuselayo zendalo kwijusi yesisu somntu. Ibonise ulungiso olubanzi lwezicubu kunye namandla okuchasa ukudumba kwizifundo zovavanyo kwaye ithathwa ngokubanzi njengomgqatswa wechiza le-peptide elithembisayo elinemisebenzi emininzi.

Njengesithako esisebenzayo samachiza (API), i-BPC-157 isetyenziswe kwiinkalo ezininzi zophando lwezenzululwazi emhlabeni jikelele ukuhlola umsebenzi wayo we-biological kwi-gastrointestinal tract, inkqubo ye-musculoskeletal, inkqubo ye-nervous, inkqubo ye-cardiovascular system kunye nokulungiswa kwezicubu ezithambileyo, ngakumbi ekulungisweni kwe-trauma kunye nophando oluchasayo.

Uphando kunye ne-pharmacological mechanism of action

I-BPC-157 ifundwe ngokubanzi, ngakumbi kwiimvavanyo zezilwanyana ze-vivo kunye neemodeli zeseli ze-vitro, kwaye ifunyenwe inezi ziphumo zilandelayo ze-pharmacological:

1. Ukuvuselelwa kwezicubu kunye nokulungiswa kwentlungu

Ikhuthaza i-tendon, i-ligament, ithambo kunye nokuvuselelwa kwezicubu ezithambileyo, kwaye inokuphucula i-angiogenesis (i-angiogenesis).

Ukukhawulezisa ukuphulukiswa kwesilonda, ukulungiswa kwangemva kokusebenza kunye nokubuyisela ukulimala kwezicubu ezithambileyo, eziye zaqinisekiswa kwiimodeli zezilwanyana ezifana nokuphuka kwe-tendon, ukunyanzeliswa kwemisipha kunye nokuphuka.

2. Ukukhuselwa kwamathumbu kunye nokulungiswa

Kwiimodeli ezifana ne-gastric ulcer, enteritis, kunye ne-colitis, i-BPC-157 inefuthe elibalulekileyo lokukhusela i-mucosal.

Iyakwazi ukumelana nomonakalo wesisu obangelwa ngamachiza achasene ne-nonsteroidal anti-inflammatory (NSAIDs) kunye nokukhuthaza ukuphulukiswa kwamathumbu emathunjini.

3. I-Anti-inflammatory kunye ne-immunomodulatory

Ilawula ukulinganisela kwe-immune system ngokuthintela izinto eziphazamisayo (ezifana ne-TNF-α, IL-6) kunye nokulawula izinto ezichasayo.

Inexabiso elinokubakho njengonyango oluncedisayo kwizifo ezingapheliyo ezivuthayo ezifana ne-** rheumatoid arthritis kunye nesifo sofuba (IBD) **.

4. I-Neuroprotection kunye ne-neurogeneration

Kwiimodeli emva kokulimala kwentambo yomgogodla, i-nerve contusion, kunye neziganeko ze-cerebrovascular, i-BPC-157 inokukhuthaza ukuvuselelwa kwenzwa kunye nokunciphisa umonakalo we-nerve.

Iyakwazi ukulwa neengxaki kwicandelo le-neuropsychiatric ezifana nokuxhalaba, ukudakumba, kunye nokuxhomekeka kotywala (inqanaba lovavanyo).

5. Ukukhuselwa kwentliziyo kunye ne-vascular

I-BPC-157 inokuphucula i-vascular permeability kwaye ikhuthaze ukulungiswa kwe-microvascular, kwaye ikholelwa ukuba inefuthe elihle kwizifo ezifana ne-myocardial ischemia, i-venous thrombosis, kunye nokulimala kwe-arterial.

Iziphumo zovavanyo kunye nophando lwangaphambili

Nangona i-BPC-157 ingekavunywa ngokubanzi kumayeza abhalwe ngabantu, ibonisile kwiimvavanyo zezilwanyana:

Ukukhawuleza okuphawulekayo kwexesha lokulungiswa kwezicubu (ezifana ne-50% yokukhawuleza ukuphulukiswa kwe-tendon)

Ukunciphisa kakhulu iziganeko zokopha kwesisu, ukulimala kwamathumbu, kunye nezilonda zekholoni

Ukuphucula ukubuyiswa kwe-nerve conduction kunye nokuphucula umsebenzi wendawo engabonakaliyo

Ukwandisa i-angiogenesis kunye nesantya sokwakheka kwezicubu zegranulation

Ngenxa yezi ziphumo, i-BPC-157 iba yimolekyuli yophando olubalulekileyo kwiinkalo zokubuyisela emva kokwenzakala, ukulimala kwezemidlalo, izifo zesisu, kunye nezifo ze-neurodeergenerative.
Ukuveliswa kwe-API kunye nokulawula umgangatho

I-BPC-157 API enikezelwa yi-Gentolex Group yethu ithatha inkqubo ye-synthesis phase synthesis (SPPS) kwaye iveliswa phantsi kweemeko ze-GMP. Inezi mpawu zilandelayo:

Ukucoceka okuphezulu: ≥99% (ukuchongwa kwe-HPLC)

Intsalela ephantsi yokungcola, akukho endotoxin, akukho ngcoliseko yentsimbi enzima

Uzinzo lwebhetshi, ukuphinda-phinda okunamandla, inkxaso yokusetyenziswa kwenqanaba lokutofa

Inkxaso yobonelelo ngegram kunye nekhilogram ukukhawulelana neemfuno zamanqanaba ahlukeneyo ukusuka kwiR&D ukuya kushishino.