I-Carbetocin yokuthintela ukuNxilwa kweSibeleko kunye ne-Postpartum Hemorrhage
Iinkcukacha zeMveliso
| Igama | I-CARBETOCIN |
| inombolo yeCAS | 37025-55-1 |
| Ifomula yemolekyuli | I-C45H69N11O12S |
| Ubunzima bemolekyuli | 988.17 |
| Inombolo ye-EINECS | 253-312-6 |
| Ukujikeleza okuthe ngqo | D -69.0 ° (c = 0.25 kwi-1M i-acetic acid) |
| Indawo yokubilisa | 1477.9±65.0 °C (Kuxelwe kwangaphambili) |
| Ukuxinana | 1.218±0.06 g/cm3(Kuxelwe kwangaphambili) |
| Iimeko zokugcina | -15°C |
| Ifomu | umgubo |
Izithethantonye
I-BUTYRYL-TYR(ME)-ILE-GLN-ASN-CYS-PRO-LEU-GLY-NH2, (SULFIDEBODBETWEENBUTYL-4-YLANDCYS);I-BUTYRYL-TYR(ME)-ILE-GLN-ASN-CYS-PRO-LEU-GLY-NH2TRIFLUOROACETATESALT;(BUTYRYL1, TYR(ME)2)-1-CARBAOXYTOC INTRIFLUOROACETATESALT;(BUTYRYL1, TYR(ME)2)-OXYTOCIN;(BUTYRYL1,TYR(ME)2)-OXYTOCINTRIFLUOROACETATESALT;I-CARBETOCIN;I-CARBETOCINTRIFLUOROACETATESALT;(2-O-METHYLTYROSINE)-DE-AMINO-1-CARBAOXYTOCIN
Umsebenzi webhayoloji
I-Carbetocin, i-oxytocin (OT) analog, i-oxytocin receptor agonist ene-Ki ye-7.1 nM.I-Carbetocin inobudlelwane obuphezulu (i-Ki = 1.17 μM) ye-chimeric N-terminus ye-oxytocin receptor.I-Carbetocin inamandla ophando lokuphuma kwegazi emva kokubeleka.I-Carbetocin inokungena kumqobo wegazi-ingqondo kwaye inomsebenzi onjenge-antidepressant ngokuvula i-oxytocin receptors kwi-CNS.
Umsebenzi
I-Carbetocin i-synthetic long-acting oxytocin 8-peptide analog with agonist properties, kunye neempawu zayo zeklinikhi kunye ne-pharmacological zifana nezo ze-oxytocin ezenzeka ngokwemvelo.Njenge-oxytocin, i-carbetocin ibophelela kwi-hormone receptors ye-uterine muscle egudileyo, ibangela ukuthotywa kwesingqisho sesibeleko, ukwandisa ukuphindaphinda kwayo kunye nokwandisa ithoni yesibeleko ngesiseko sokuqhawula kweyokuqala.Amanqanaba e-Oxytocin receptor kwisibeleko aphantsi kwimeko engakhulelwanga, ukwanda ngexesha lokukhulelwa, kunye nencopho ngexesha lokubeleka.Ngoko ke, i-carbetocin ayinayo impembelelo kwisibeleko esingakhulelwanga, kodwa inefuthe elinamandla le-contractile ye-uterine kwisibeleko esikhulelweyo kunye nesibeleko esandula kuveliswa.
Guqula iziLawuli
Utshintsho lulawulwa ngokwenkqubo.Ngokusekelwe kwimpembelelo kunye nomngcipheko kunye nobunzima, utshintsho luhlelwa njengoMkhulu, omncinci kunye neSiza.Utshintsho lwesiza lunempembelelo encinci kukhuseleko kunye nomgangatho wemveliso, kwaye ke akudingi mvume kunye nesaziso kumthengi;Utshintsho oluncinci lunempembelelo ephakathi kukhuseleko kunye nomgangatho wemveliso, kwaye kufuneka ukwazisa umthengi;Utshintsho olukhulu lunempembelelo ephezulu kukhuseleko kunye nomgangatho wemveliso, kwaye kufuneka imvume yomthengi.
Ngokwenkqubo, ulawulo lotshintsho luqalwa ngesicelo sotshintsho apho iinkcukacha zotshintsho kunye nengqiqo yotshintsho zichazwe.Uvandlakanyo lwenziwa emva kwesicelo, olwenziwa ngotshintsho lwamasebe afanelekileyo.Ngeli xesha, ulawulo lotshintsho luhlelwa kwinqanaba eliKhulu, inqanaba ngokubanzi kunye nenqanaba eliNcinci.Emva kovavanyo olufanelekileyo kunye nokuhlelwa, lonke utshintsho lwenqanaba kufuneka luvunywe nguMphathi we-QA.Ulawulo lotshintsho lwenziwa emva kokuvunywa ngokwesicwangciso somsebenzi.Ulawulo lwenguqu ekugqibeleni luvalwe emva kokuba i-QA iqinisekisa ukuba ulawulo lwenguqu luphunyezwe ngokufanelekileyo.Ukuba ubandakanya isaziso somthengi, umxhasi kufuneka aziswe kwangethuba emva kokuba ulawulo lotshintsho luvunyiwe
