I-Linaclotide ye-Gastrointestinal Disorders 851199-59-2
Iinkcukacha zeMveliso
| Igama | I-Linaclotide |
| inombolo yeCAS | 851199-59-2 |
| Ifomula yemolekyuli | I-C59H79N15O21S6 |
| Ubunzima bemolekyuli | 1526.74 |
Izithethantonye
ILinacllotide;Linaclotide;LinaelotideAcetate;Linaelotide;CY-14;Liclotide;Argpessin;L-Tyrosine,L-cysteinyl-L-cysteinyl-L-α-glutamyl-L-tyrosyl-L-cysteinyl-L-cysteinyl-L-asparaginyl- L-prolyl-L-alanyl-L-cysteineyl-L-threonylglycyl-L-cysteineyl-,cyclic(1→6),(2→10),(5→13)-tris(disulfide)
Inkcazo
I-Linaclotide, i-synthetic peptide structure equlethe i-14 amino acids, inxulumene ne-endogenous guanosine peptide family kwaye kuphela kwe-FDA-evunywe yi-GC-C (guanylate) Cyclase-C) iziyobisi ze-agonist kunyango lwe-irritable bowel syndrome kunye nokuqhina (IBS- C) kunye ne-idiopathic constipation engapheliyo (CIC) kubantu abadala.
Iipropati zeMichiza
I-Linaclotide ngumgubo omhlophe omhlophe we-amorphous;inyibilika kancinane emanzini kunye nesisombululo se-sodium chloride emanzi (0.9%).
Ingaba isebenza kanjani
I-Linaclotide yi-guanylate cyclase-C receptor agonist (GCCA) ene-visceral analgesic kunye nomsebenzi we-endocrine.Bobabini i-linaclotide kunye ne-metabolite yayo esebenzayo inokubophelela kwi-guanylate cyclase-C (GC-C) i-receptor kwi-luminal surface ye-epithelium yamathumbu amancinci.Kwiimodeli zezilwanyana, i-linaclotide inciphisa intlungu ye-visceral kwaye inyuse ukuhamba kwesisu ngokusebenza kwe-GC-C, kwaye ebantwini, ichiza likwanyusa i-colonic transit.Isiphumo sokusebenza kwe-GC-C kunyuswe kwi-intracellular kunye ne-extracellular cGMP (i-cyclic guanosine monophosphate) yoxinaniso.I-cGMP ye-Extracellular inokunciphisa umsebenzi weentlungu ze-nerve fibers kunye nokunciphisa intlungu ye-visceral kwimodeli yezilwanyana.I-Intracellular cGMP inokunyusa i-secretion ye-chloride kunye ne-bicarbonate emathunjini amancinci ngokuvula i-CFTR (i-cystic fibrosis transmembrane conductance regulator), ekugqibeleni ikhokelela ekwandeni kwe-intestinal encinci ye-intestinal secretion kunye nesantya sokuhamba kwamathumbu amancinci.
FAQ
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