Ganirelix Acetate Peptide API

Inkcazelo emfutshane:

Igama: Ganirelix Acetate

Inombolo ye-CAS: 123246-29-7

Ifomula yemolekyuli: C80H113ClN18O13

Ubunzima bemolekyuli: 1570.34

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Iinkcukacha zeMveliso

Iithegi zeMveliso

Iinkcukacha zeMveliso

Igama	Ganirelix Acetate
inombolo yeCAS	123246-29-7
Ifomula yemolekyuli	I-C80H113ClN18O13
Ubunzima bemolekyuli	1570.34

Izithethantonye

Ac-DNal-DCpa-DPal-Ser-Tyr-DHr(Et2)-Leu-Har(Et2)-Pro-DAla -NH2;Ganirelixum;ganirelix Acetate;GANIRELIX;Ganirelix Acetate USP/EP/

Inkcazo

I-Ganirelix i-synthetic decapeptide compound, kunye netyuwa ye-acetate, i-Ganirelix acetate yi-gonadotropin-releasing hormone (GnRH) i-receptor antagonist.Ulandelelwano lwe-amino acid lu: Ac-D-2Nal-D-4Cpa-D-3Pal-Ser-Tyr-D-HomoArg(9,10-Et2)-Leu-L-HomoArg(9,10-Et2)-Pro- D- Ala-NH2.Ngokukodwa eklinikhi, isetyenziswa kubasetyhini abafumana itekhnoloji yokuncedisa ekuzaleni elawulwa ziinkqubo zokuvuselela i-ovarian ukunqanda incopho yehomoni ye-luteinizing ngaphambi kwexesha kunye nokunyanga ukuphazamiseka kokuzala ngenxa yesi sizathu.Ichiza lineempawu zokusabela okungathandekiyo, izinga eliphezulu lokukhulelwa kunye nexesha elifutshane lonyango, kwaye lineenzuzo ezicacileyo xa kuthelekiswa namachiza afanayo ekusebenzeni kweklinikhi.

Isenzo se-Pharmacological

Ukukhutshwa kwe-pulsatile ye-gonadotropin-releasing hormone (GnRH) ivuselela i-synthesis kunye nokukhutshwa kwe-LH kunye ne-FSH.I-frequency ye-LH pulses kwi-mid and late follicular phases imalunga ne-1 ngeyure.Ezi pulses zibonakaliswa ngokunyuka okwethutyana kwi-serum LH.Ngexesha lexesha eliphakathi lokuya exesheni, ukukhutshwa okukhulu kwe-GnRH kubangela ukunyuka kwe-LH.Utyando lwe-LH lwaphakathi exesheni lunokubangela iimpendulo ezininzi zomzimba, ezibandakanya: ukukhutshwa kweqanda, ukuqalisa kwakhona kwe-oocyte meiotic, kunye nokwakheka kwe-corpus luteum.Ukuqulunqwa kwe-corpus luteum kubangela ukuba amanqanaba e-serum progesterone anyuke, ngelixa amanqanaba e-estradiol ehla.I-Ganirelix i-acetate ngumchasi we-GnRH okhuphisanayo ovimba i-GnRH i-receptors kwi-pituitary gonadotrophs kunye neendlela zokudluliselwa okulandelayo.Ivelisa ngokukhawuleza, ukuguqulwa kwe-inhibition ye-gonadotropin secretion.Impembelelo ye-inhibitory ye-ganirelix acetate kwi-pituitary LH secretion yayinamandla kunaleyo kwi-FSH.I-Ganirelix acetate ayiphumelelanga ukukhuthaza ukukhutshwa kokuqala kwe-gonadotropins engapheliyo, ehambelana nokuchasana.Ukuchacha ngokupheleleyo kwe-pituitary LH kunye namanqanaba e-FSH kwenzeka kwiiyure ezingama-48 emva kokuba i-ganirelix acetate iyekwa.

Ngaphambili: I-Cetrorelix Acetate yokunqanda i-Ovulation ngaphambi kwexesha 120287-85-6

Okulandelayo: I-Linaclotide ye-Gastrointestinal Disorders 851199-59-2

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