I-Semaglutide yohlobo lwe-2 yeswekile
Iinkcukacha zeMveliso
| Igama | Semaglutide |
| inombolo yeCAS | 910463-68-2 |
| Ifomula yemolekyuli | C187H291N45O59 |
| Ubunzima bemolekyuli | 4113.57754 |
| Inombolo ye-EINECS | 203-405-2 |
Izithethantonye
I-Sermaglutide;I-Semaglutide fandachem;ukungcola kweSemaglutide;I-Sermaglutide USP/EP;i-semaglutide;I-Sermaglutide CAS 910463 68 2;Ozempic,
Inkcazo
I-Semaglutide isizukulwana esitsha se-GLP-1 (i-glucagon-like peptide-1) analogues, kwaye i-semaglutide yifom yedosi yexesha elide ephuhliswe ngokusekelwe kwisiseko esisisiseko se-liraglutide, enempembelelo engcono kunyango lwe-2 yeswekile.I-Novo Nordisk iye yagqiba izifundo ze-6 zeSigaba se-III ze-semaglutide injection, kwaye ingenise isicelo esitsha sokubhaliswa kweyeza semaglutide ngeveki kwi-US Food and Drug Administration (FDA) ngoDisemba 5, 2016. Isicelo sokuGunyanyiswa kweNtengiso (MAA) nayo yathunyelwa i-Arhente yaMayeza yaseYurophu (EMA).
Xa kuthelekiswa ne-liraglutide, i-semaglutide ine-aliphatic chain ende kunye nokunyuka kwe-hydrophobicity, kodwa i-semaglutide iguqulwa ngekhonkco elifutshane le-PEG, kwaye i-hydrophilicity yayo iphuculwe kakhulu.Emva kokuguqulwa kwe-PEG, ayikwazi ukubopha ngokusondeleyo kwi-albumin, ukugubungela indawo ye-enzymatic hydrolysis ye-DPP-4, kodwa nokunciphisa ukukhutshwa kwezintso, ukwandisa ixesha le-biological half-life, kunye nokufezekisa umphumo wokujikeleza ixesha elide.
Isicelo
I-Semaglutide yindlela yokulinganisa ixesha elide eliphuhliswe ngokusekelwe kwisiseko esisisiseko se-liraglutide, esisebenza ngakumbi ekuphatheni uhlobo lwe-2 yeswekile.
Ukusebenza kwezinto eziphilayo
I-Semaglutide (Rybelsus, Ozempic, NN9535, OG217SC, NNC0113-0217) yi-glucagon-efana ne-peptide ye-1 (GLP-1) i-analog, i-agonist ye-GLP-1receptor, kunye nohlobo olunokubakho lwe-2 Unyango olusebenzayo lwe-T2DM yesifo sikashukela. ).
Inkqubo esemgangathweni
Ngokubanzi, inkqubo yomgangatho kunye nesiqinisekiso sikhoyo sigubungela onke amanqanaba okuveliswa kwemveliso egqityiweyo.Imisebenzi eyaneleyo yokwenziwa kwemveliso nolawulo iyenziwa ngokuhambelana neenkqubo/imigaqo evunyiweyo.Ulawulo lotshintsho kunye nenkqubo yokuphatha ukutenxa ikhona, kwaye uvavanyo lwempembelelo oluyimfuneko kunye nophando lwenziwa.Iinkqubo ezifanelekileyo zikhona ukuqinisekisa umgangatho wemveliso ngaphambi kokuba ikhutshwe kwimarike.
