Atosiban Acetate Used for Anti Premature Birth Featured Image

I-Atosiban Acetate isetyenziselwa ukuzalwa kwangaphambili

Inkcazelo emfutshane:

Igama: Atosiban

Inombolo ye-CAS: 90779-69-4

Ifomula yemolekyuli: C43H67N11O12S2

Ubunzima bemolekyuli: 994.19

Inombolo ye-EINECS: 806-815-5

Indawo yokubila: 1469.0±65.0 °C (Kuqikelelwe)

Ubuninzi: 1.254±0.06 g/cm3(Kuqikelelwe)

Iimeko zokugcina: -20°C

Ukunyibilika: H2O: ≤100 mg/mL

Thumela i-imeyile kuthi

Iinkcukacha zeMveliso

Iithegi zeMveliso

Iinkcukacha zeMveliso

Igama	Atosiban
inombolo yeCAS	90779-69-4
Ifomula yemolekyuli	I-C43H67N11O12S2
Ubunzima bemolekyuli	994.19
Inombolo ye-EINECS	806-815-5
Indawo yokubilisa	1469.0±65.0 °C (Kuxelwe kwangaphambili)
Ukuxinana	1.254±0.06 g/cm3(Kuxelwe kwangaphambili)
Iimeko zokugcina	-20°C
Ukunyibilika	H2O:≤100 mg/mL

Inkcazo

I-atosiban acetate yi-disulfide-bonded cyclic polypeptide equkethe i-9 amino acids.Yimolekyuli ye-oxytocin elungisiweyo kwiindawo ze-1, 2, 4 kunye ne-8. I-N-terminus ye-peptide yi-3-mercaptopropionic acid (thiol kunye neqela le-sulfhydryl ye [Cys] 6 yenza ibhondi ye-disulfide), i-C-terminal ngendlela ye-amide, i-amino acid yesibini kwi-N-terminal i-ethylated modified [D-Tyr (Et)] 2, kunye ne-atosiban acetate isetyenziselwa amayeza njengeviniga Ikhona kwimo yetyuwa ye-asidi, ngokuqhelekileyo. eyaziwa ngokuba yi-atosiban acetate.

Isicelo

I-Atosiban yi-oxytocin kunye ne-vasopressin ye-V1A edibeneyo ye-receptor antagonist, i-oxytocin receptor ifana nesakhiwo esifana ne-vasopressin V1A receptor.Xa i-oxytocin receptor ivaliwe, i-oxytocin isenokuthi isebenze nge-V1A receptor, ngoko ke kuyimfuneko ukuvala iindlela ezimbini ze-receptor ngexesha elifanayo, kunye ne-antagonism enye ye-receptor enye inokuthintela ngokufanelekileyo ukuchithwa kwe-uterine.Esi sesinye sezizathu eziphambili zokuba kutheni i-β-receptor agonists, i-calcium channel blockers kunye ne-prostaglandin synthase inhibitors ayikwazi ukuthintela ngokufanelekileyo ukuchithwa kwesibeleko.

Isiphumo

I-Atosiban ngumchasi we-receptor odibeneyo we-oxytocin kunye ne-vasopressin V1A, ukwakheka kweekhemikhali kufana nezi zibini, kwaye inobudlelwane obuphezulu be-receptors, kwaye ikhuphisana ne-oxytocin kunye ne-vasopressin V1A receptors, ngaloo ndlela ivimbela indlela yesenzo se-oxytocin kunye ne-vasopressin kunye nokunciphisa. ukuqhawuka kwesibeleko.

Ngaphambili: Teriparatide Acetate API for Osteoporosis CAS NO.52232-67-4

Okulandelayo: I-Carbetocin yokuthintela ukuNxilwa kweSibeleko kunye ne-Postpartum Hemorrhage

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