Cagrilintide

Inkcazelo emfutshane:

I-Cagrilintide i-synthetic, i-amylin receptor agonist yexesha elide iphuhliswe ukunyangwa kokukhuluphala kunye nokuphazamiseka kwe-metabolic ezinxulumene nobunzima. Ngokulinganisa ihomoni yendalo i-amylin, inceda ukulawula ukutya, ukucotha kwesisu, kunye nokuphucula ukuhlutha. I-API yethu ephezulu ye-Cagrilintide API iveliswa ngokusebenzisa i-chemical synthesis kwaye idibana nemigangatho yemigangatho ye-pharmaceutical-grade, eyenza ifaneleke ukusetyenziswa kwiifom zokulawula ubunzima obuphezulu.

Thumela i-imeyile kuthi

Iinkcukacha zeMveliso

Iithegi zeMveliso

Cagrilintide API

Cagrilintideyinto esebenza ixesha elide, eyenziwe ngamachizai-amylin receptor agonist, iphuhliswe njengonyango lwenoveliukutyeba kunye nobunzima obunxulumene nokuphazamiseka kwemetabolism. Yenzelwe ukulinganisa iziphumo zeamylin yomntu, ihomoni edityaniswe ne-insulin yi-pancreatic β-cell, edlala indima ebalulekileyo ekulawuleni ukutya, ukukhupha isisu kunye nokuhlutha.

ICagrilintide iphuhliswa njengeKanye ngeveki unyango olutofwayo, enikezela ngesisombululo esithembisayo kakhuluulawulo lobunzima obungapheliyo, ngakumbi xa isetyenziswa kwiukudibanisa ne-GLP-1 i-receptor agonistsnjengeSemaglutide.

Indlela yokwenza

I-Cagrilintide yenza iziphumo zayo zonyango ngokuzibophelela kunye nokusebenzai-amylin receptors, ikhokhelela kwi:

Ukucinezelwa kokutya
Ukulibaziseka kokukhupha isisu, eyandisa imvakalelo yokuhlutha
Ukunciphisa ikhalori kunye nokunyuka kwe-satiety

Lo mmiselo we-multimodal wokuthathwa kokutya kwenza kube ngumgqatswa ofanelekileyo wokulawulaukutyeba kakhulu kunye neengozi ezinxulumene ne-cardiometabolic.

Uphando kunye neeNkcukacha zeKlinikhi

I-Cagrilintide ibonise iziphumo ezithembisayo kwiimvavanyo ezininzi zeklinikhi, kuqukaIzifundo zeSigaba se-2 eziqhutywe nguNovo Nordisk:

Xa isetyenziswayedwa, iCagrilintide ikhokelela kwiukuncipha kobunzima obuxhomekeke kwidosi, kunye ukuyaI-10.8% yokunciphisa umzimbangaphezu kweeveki ezingama-26 kubantu abatyebe kakhulu.
Niniidibene neSemaglutide, umphumo wokulahlekelwa kwesisindo uphuculwe kakhulu-ukuphumelelaukunciphisa okukhulu kubunzima bomzimba kune-arhente yodwa.
Ibonisileukunyamezela okulungileyokwayeiprofayili yokhuseleko oluzinzileyo, kunye neziganeko ezimbi kakhulu iimpawu zesisu esiswini.

Le ndlela yokudibanisa yinxalenye ephambili yeumbhobho weyeza lokulwa ukutyeba kwisizukulwana esilandelayo, kujoliswe kwiindlela ezininzi zokuhlutha (i-amylin + GLP-1).

Umgangatho we-API kunye nokuVeliswa

YethuCagrilintide API:

Iveliswa ngokuphambilii-soli-phase peptide synthesis (SPPS)ngokucoceka okuphezulu kunye nokuzinza kweekhemikhali
Yenzelweuphuhliso lokwenziwa kweetofu
Udibana namazwe ngamazweimigangatho yamayeza (ICH, GMP, FDA)
Iyafumaneka kwiulinge kwimveliso yorhwebo, ilungele ukusetyenziswa kweklinikhi kunye nezoshishino

Amandla oNyango

ICagrilintide imele aindlela entshakulawulo lobunzima ngaphaya kwe-GLP-1 monotherapy. Iprofayile yentshukumo ehambelanayo iyenza ilungele:

Ukutyeba kakhulu kunye nezigulana ezityebileyo(neswekile okanye ngaphandle kwayo)
Unyango oludibeneyoukwenzela ukunciphisa umzimba
Uphuhliso lwexesha elizayo kwiisifo se-metabolic kunye ne-prediabetes