CJC-1295

CJC-1295 API

CJC-1295yi-synthetic, i-tetrasubstituted peptide analogue yeIhomoni yokukhula ekhupha ihomoni (GHRH), yenzelwe ukubaukuvuselela kunye nokugcina ukukhuselwa kwe-hormone yokukhula engapheliyo (GH). Ngokungafaniyo ne-GHRH yasekhaya, enobomi obufutshane obufutshane, i-CJC-1295 idibanisa aItekhnoloji yeDrug Affinity Complex (DAC)., ukuvumela ukuba ibophe ngokudibeneyo kwi-albumin egazini kunyeyandisa isiqingatha sobomi bayo bebhayoloji ukuya ngaphezulu kweentsuku ezisi-8. Olu tshintsho lwenza i-CJC-1295 aI-analogue ye-GHRH esebenza ixesha elidengesakhono esibalulekileyo kwianti-ukuguga, ukusilela ukukhula, ukulawulwa kwe-metabolic, ukuphazamiseka kokumosha izihlunu, kunye neyeza lokuvuselela.

Indlela yokwenza

CJC-1295 izenzo kwiGHRH receptoribekwe kwiiseli ze-somatotropic kwi-anterior pituitary gland. Umsebenzi wayo webhayoloji ulinganisa nowomthonyama we-GHRH, kodwa ngesiqingatha sobomi obandisiweyo ngenxa yohlengahlengiso lweDAC. Esi senzo sihlala sisenza sikwaziukukhutshwa okuzinzileyo kwe-GHkunye nokwanda kwemvelisoI-insulin-efana ne-insulin factor 1 (IGF-1).

Iindlela eziphambili ziquka:

• Ukuvuselela imfihlo ye-GH engapheliyo

• Ukuphakama kwexesha elide lamanqanaba e-IGF-1, ukuxhasa iziphumo ze-anabolic

• Akukho buthathakaokanye ukuthotywa ngokusetyenziswa rhoqo

• I-lipolysis eyandisiweyo, iprotein synthesis, kunye nokuvuselelwa kwamaselula

Ngokubangela umzimba we-GH kunye ne-IGF-1 iindlela, i-CJC-1295 ithintela ezininzi iingxaki ezinxulumene nonyango lwe-GH exogenous, njenge-receptor deensitization kunye neenkxalabo zokhuseleko.

UPhando lwezoNyango kunye namandla oNyango

1. Ukunqongophala kweHormone yokukhula (GHD)

Kwizilingo zekliniki zesigaba sokuqala, i-CJC-1295 ibonise:

• Ukunyuka okuzinzileyo kwiGHkwayeIGF-1amanqanaba ukuya kuthi ga6-10 iintsukuemva kwesitofu esinye

• NciphisiweIsitofu rhoqoxa kuthelekiswa nemihla ngemihla ye-GHRH analogues okanye iinaliti zeGH

• Ukuphuculwa kokuthotyelwa kwesigulane kunye nokuzinza kwehomoni

2. Ukubunjwa komzimba kunye nokuGcinwa kwemisipha

Izifundo zezilwanyana kunye nabantu zibonise ukuba i-CJC-1295:

• Iyanyusaukuzuza kwezihlunu ezibhityileyokwayekunciphisa amafutha omzimba, ngakumbi amafutha e-visceral

• Iyaphuculaukugcinwa kwenitrogen kunye neprotein synthesiskwisihlunu samathambo

• Ngamana uncedo ekuchacheni ukusukai-sarcopeniakunye neemeko zokuchithwa kwemisipha

3. Anti-Ukuguga kunye Wellness Application

Njengoko amanqanaba e-GH kunye ne-IGF-1 ngokwemvelo ehla ngokukhula, i-CJC-1295 isanda kufundwa njengeungenelelo lokuchasa ukugugaukuya:

• Phuculaumgangatho wokulalakwayeummiselo wesigqi esijikelezayo

• Ukuphuculaukuqina kwesikhumba, ukuxinana kwamathambo, kwayeumsebenzi omzimba

• Inkxasoi-metabolism yamandlakwayeukumelana nokudinwa

4. Ulawulo lweMetabolic

I-CJC-1295 ibonisa isithembiso ekuphenduleniukumelana ne-insulinkunye nesifo se-metabolic ngu:

• Ukuphuculaukusetyenziswa kweglucose

• Ukuphuculai-lipid oxidationkwayei-adipose tissue metabolism

• Ukuxhasaulawulo lobunzimakubantu abatyebe kakhulu okanye aba pre-diabetes

Ukwenziwa kwe-API kunye noLawulo loMgangatho

At Iqela leGentolex, wethuCJC-1295 APIiveliswa kusetyenziswai-soli-phase peptide synthesis (SPPS)kwaye ihlanjululwe kusetyenziswa i-HPLC ukufezekisa ubunyulu obuphezulu kunye ne-batch-to-batch consistency.

IiNgcaciso eziphambili:

• Ubunyulu ≥ 99%(i-HPLC iqinisekisiwe)

• Izinyibilikisi ezishiyekileyo ezisezantsi kunye neentsimbi ezinzima

• Indlela ye-endotoxin-free, non-immunogenic synthesis

• Ifumaneka kwiimiyinge yesiko: milligram ukuya kwisikali seekhilogram

Izicelo kunye nokubanakho kwekamva

I-CJC-1295 ithathwa njengenye ye-analogue ye-GHRH ethembisayo yexesha elide, enezicelo ezinokuthi:

• Unyango lokunqongophala kwe-GH yabantu abadala

• Ulawulo lokwakheka komzimba ekutyebeni nasekugugeni

• Ukubuyiselwa kwimeko yokulahlekelwa kwemisipha okanye ukwenzakala

• Ukuphuculwa kokusebenza kunye nokubuyisela kwimeko yeklinikhi okanye yezemidlalo

• Unyango oluxhasayo ekukhathaleni okungapheliyo, i-fibromyalgia, kunye nokungalingani kwe-neuroendocrine

Ulingo lweklinikhi oluqhubekayo luphonononga ukusetyenziswa kwayo njengenye indlelarecombinant GH, ngakumbi kubantu abafunayoikhuselekile, ngakumbi ukuguqulwa kwehomoni yomzimba.