Elamipretide

Elamipretide API

I-Elamipretide yi-tetrapeptide ejoliswe kwi-mitochondria ephuhliswe ukunyanga izifo ezibangelwa ukungasebenzi kakuhle kwe-mitochondrial, kubandakanywa ne-myopathy ye-mitochondrial ephambili, i-Barth syndrome, kunye nokusilela kwentliziyo.

Inkqubo kunye noPhando:
I-Elamipretide ijolise ngokukhethekileyo kwi-cardiolipin kwi-membrane ye-mitochondrial yangaphakathi, iphucula:
Mitochondrial bioenergetics
Ukuveliswa kwe-ATP
Ukuphefumla kweeseli kunye nokusebenza kwamalungu

Ibonise amandla okubuyisela isakhiwo se-mitochondrial, ukunciphisa uxinzelelo lwe-oxidative, kunye nokuphucula ukusebenza kwemisipha kunye nentliziyo kwizifundo zombini zeklinikhi kunye nezangaphambili.