Fmoc-L-Lys[Eic(OtBu)-γ-Glu(OtBu)-AEEA]-OH

Fmoc-L-Lys[Eic(OtBu)-γ-Glu(OtBu)-AEEA]-OH

Isicelo soPhando:
Le khompawundi lukhuselweyo, lusebenza ngokuphuma kwi-lysine esetyenziswa kwi-peptide synthesis kunye nophuhliso lwe-conjugate yeziyobisi. Ibonisa iqela le-Fmoc lokukhusela i-N-terminal, kunye nokuguqulwa kwe-side-chain kunye ne-Eic (OtBu) (i-eicosanoic acid derivative), i-γ-glutamic acid (γ-Glu), kunye ne-AEEA (aminoethoxyethoxyacetate). La macandelo enzelwe ukufunda iziphumo ze-lipidation, i-spacer chemistry, kunye nokukhutshwa kweziyobisi ezilawulwayo. Iphandwa ngokubanzi kumxholo wezicwangciso zeprodrug, i-ADC linkers, kunye ne-membrane-interacting peptides.

Umsebenzi:
I-Fmoc-L-Lys[Eic (OtBu)-γ-Glu (OtBu)-AEEA] -OH isebenza njengebhloko yokwakha ukudibanisa i-lipid-modified peptides okanye iinkqubo zokuhanjiswa kweziyobisi. I-Eic moiety iphucula i-lipophilicity kunye ne-membrane yokubopha; I-γ-Glu yongeza uzinzo lwe-enzymatic kunye namandla okujolisa; kunye ne-AEEA isebenza njenge-flexible hydrophilic linker. Ngokudibeneyo, bavumela ukwakhiwa kwee-peptides ngokuthathwa kweselula okongeziweyo, ukongezwa kwesiqingatha sobomi, kunye neempawu zokuhanjiswa kwesiza.