Fmoc-L-Lys[Ste(OtBu)-γ-Glu-(OtBu)-AEEA-AEEA]-OH

Fmoc-L-Lys[Ste(OtBu)-γ-Glu(OtBu)-AEEA-AEEA]-OH

Isicelo soPhando:
Le khompawundi yi-lysine derivative eguquliweyo esetyenziswa kwi-peptide synthesis, ngakumbi ekwakheni i-conjugates yepeptide ekujoliswe kuyo okanye esebenzayo. Iqela le-Fmoc livumela ukuhlanganiswa kwe-stepwise nge-Fmoc solid-phase peptide synthesis (SPPS). Ikhonkco elisecaleni liguqulwa kunye ne-stearic acid derivative (Ste), γ-glutamic acid (γ-Glu), kunye ne-AEEA (aminoethoxyethoxyacetate) ezimbini zokudibanisa, ezibonelela nge-hydrophobicity, iipropati zentlawulo, kunye ne-flexible spacing. Iqhele ukufundwa ngendima yayo kwiinkqubo zokuhanjiswa kweziyobisi, kubandakanywa i-antibody-drug conjugates (ADCs) kunye neepeptides ezingena kwiseli.

Umsebenzi:
I-Fmoc-L-Lys[i-Ste(OtBu)-γ-Glu(OtBu)-AEEA-AEEA]-OH isebenza njengebhloko yokwakha ekuphuhliseni i-peptides ye-lipidated ye-long-chain okanye i-drug-linker complexes. I-asidi ye-stearic iphakamisa ubudlelwane be-membrane, i-γ-Glu iphucula ukuzinza kunye nokuxhatshazwa kwe-enzymatic, kunye ne-AEEA izixhumanisi zibonelela nge-solubility kunye nokuguquguquka kwesakhiwo. Ngokudibeneyo, ezi mpawu zenza i-compound ixabiseke ekuyileni i-peptides yokuphuculwa kwe-bioavailability, ukukhutshwa okulawulwayo, kunye nezicelo ezijoliswe kuzo zokuhanjiswa.