I-Ibutamoren Mesylate yonyusa ingeniso yomzimba, i-Serum Ig-1 kunye ne-GHRE
Iinkcukacha zemveliso
| Igama | Ibutamoren mesylate |
| Inombolo ye-CAS | I-159752-10-0 |
| Ifomula yemolekyuli | C28h40n4O8S2 |
| Ubunzima bemolekyuli | I-624.77 |
| Inombolo ye-einecs | 1308068-626-2 |
| Indawo yokunyibilika | 164-170 ° C |
| Ukunyibilikisa | H2o: inyibilikisi / ml, icacile |
| Imeko yokugcina | I-2-8 ° C |
| Ifom | Umgubo |
| Umbala | Mhlophe kwi-beige |
| Ukupakisha | Ibhegi ye-PE + i-aluminium Bag |
Izithethantonye
I-MK-677; I-2-Aminino-N - [(1R) -2- [1,2 ye-1,2-(i-3- (i-3- idin]-1'-yl]-2-oxo-1-[(phenylmethoxy)methyl]ethyl]-2-methylpropanamidemethanesulfon I-MK677 (i-Ibutarerensets); I-MK-677; I-Crescendo; mk0677; mk677; mk677; mk677; c S-1402; mk677mk677ibutamoren; mk677mk67777ibutamoren, whi63.com; mk677, mk677
Isiphumo se-Pharmacociological
Inkcazo
I-Ibramolen Meylates lichiza elisebenza njengezilolo ezinamandla, ezinamandla aphezulu, ukukhula-ukukhula, ukuvuselela isenzo se-GH ukukhuthaza iihomoni ze-endogenous.
Umsebenzi
I-Ibramolen Mesylate ibonisiwe ukwandisa ukukhutshwa kunye nokuvelisa amanqanaba ePlasma kuquka iihomoni ezithile ze-HH kunye ne-Igf-1), kodwa ayichaphazeleki amaCortool. Unyango olunokubakho kungoku nje uphuhliso lunciphise amanqanaba eehomoni, njengakwabantwana okanye abantu abalupheleyo ngokukhula kwe-hormone, kwaye izifundo zoluntu zibonise ukunyuka kwemisipha kunye nokwenza unyango oluthembisayo kubantu abadala ababuthathaka. Ikwatshintsha imetabolism yamafutha omzimba, ke isenokuba nezicelo kunyango lokutyeba kakhulu.
Kwizifundo ze-VIVO
I-Ibutamoren Mesylate (i-5 mg / kg / kg / usuku) kwiziphumo ezibalulekileyo ze-Fines Inzuzo yomzimba kunye nokunyusa i-serum Ig-1 kunye ne-GH amanqanaba ezinja. I-Ibutamoren Meylates iziphumo zingabi nako olwando olubalulekileyo kwi-CSF Igf-1 okanye amanqanaba e-GH kwiintsuku ezisi-7 okanye ezili-15 zophando. Imayile eguqukayo kunye neebhloko ze-GH iibhloko zokuvula ezi neurons ze-Ibutamoren Mesylate (50 μg, ip). Kwi-theckout yeempuku, zombini GH kunye ne-octretide iyasilela ukuthintela i-Ibratyamoren Meylates Ulawulo lwe-orch elingapheliyo lwe-MK-0677 lunxulunyaniswa nokunyuka okukhulu kwi-GH kunye ne-IGF-IIQUNI ZOKUGCINWA KWEXESHA LOLUNTU. Iprofayili ye-GH-0677 Ulawulo luquka ukonyuka kwe-Epsodic lolawulo. I-MK-0677 inyusa kakhulu i-Peak Gh igxile emva kolawulo lomlomo. I-MK-0677 yi-GHE GeagogueOgue efaka ulwando olukhawulezileyo, olukhulu, oluhlala ixesha elide, oluhlala ixesha elide.
