I-Chondroitin Sulfate yoNyango lwe-Coronary Heart Disease, i-Arthritis kunye nokuPhiliswa kwe-Corneal Wounds Purity 98%

Inkcazo

I-Chondroitisulfate (CS) yi-acidic mucopolysaccharide ekhutshwe kwaye ihlanjululwe kwi-cartilage yezilwanyana.I-Chondroitin sulfate inezakhiwo ezahlukeneyo ezifana ne-A, C, D, E, H kunye ne-K. I-Chondroitin sulfate kwindalo ifumaneka kwi-cartilage yezilwanyana, ithambo lomqala, ithambo lempumlo (i-41% yeehagu), i-bovine, i-septum yehashe kunye ne-trachea (equlethe I-36% ukuya kwi-39%), ezinye izicubu ezinjengamathambo omlenze, iigaments, isikhumba, i-cornea, njl.Umxholo we-fish cartilage ucebile kakhulu, njenge-50% ukuya kwi-60% kwithambo le-shark, kwaye incinci kakhulu kwi-tissue edibeneyo.

Kwisifo se-coronary atherosclerotic, ukunyuka kwe-lipids yegazi kunye ne-cholesterol, i-arteriosclerosis, i-angina pectoris, i-myocardial ischemia, i-myocardial infarction, njl. kwizigulane ezine-coronary heart disease.

Isenzo se-Pharmacological

I-Rapamycin (RAPA) ineziphumo ebezingalindelekanga ezifanayo kwi-FK506.Kwinani elikhulu leemvavanyo zeklinikhi, iziphumo zayo ebezingalindelekanga zifunyaniswe zixhomekeke kwidosi kwaye zibuyela umva, kwaye i-RAPA kumayeza onyango ayifunyaniswanga inephrotoxicity ebalulekileyo kwaye akukho gingival hyperplasia.Eyona tyhefu kunye neziphumo ebezingalindelekanga ziquka: intloko ebuhlungu, isicaphucaphu, isiyezi, ukopha, kunye neentlungu ezihlangeneyo.Izinto ezingaqhelekanga zaseLabhoratri ziquka: i-thrombocytopenia, i-leukopenia, i-hemoglobin ephantsi, i-hypertriglyceridemia, i-hypercholesterolemia, i-hyperglycemia, i-enzymes yesibindi ephakamileyo (i-SGOT, i-SGPT), i-lactate dehydrogenase ephezulu, i-hypokalemia, i-Hypomagnesemia, njl. Amanqanaba e-plasma phosphate kucingelwa ukuba yi-phosphate excretion ende ukusuka kwi-intso etshintshelwe yi-RAPA-based immunosuppressive therapy.Njengezinye ii-immunosuppressives, i-RAPA inamathuba awongezelelekileyo osulelo, kunye notyekelo oluxeliweyo lokunyusa inyumoniya ngokukodwa, kodwa ukwenzeka kolunye usulelo olungenelelayo akwahlukanga kakhulu kwi-CsA.

Iziphumo zeToxicological

I-Chondroitin sulfate ikhona ngokubanzi kwi-cartilage yabantu kunye nezilwanyana.Ukulungiswa kwamayeza ikakhulukazi kuqulethe i-isomers ezimbini ze-chondroitin sulfate A kunye ne-chondroitin sulfate C, kunye nomxholo we-chondroitin sulfate kwi-cartilage yezilwanyana zeentlobo ezahlukeneyo kunye neminyaka eyahlukileyo.Iziphumo zayo ze-pharmacological zilandelayo: i-chondroitin sulfate inokususa i-lipids kunye ne-lipoproteins egazini, isuse i-cholesterol kwimithambo yegazi ejikeleze intliziyo, ikhusele kwaye iphathe i-atherosclerosis, kwaye yandise izinga lokuguqulwa kwe-lipids kunye ne-fatty acids kwiiseli.I-Chondroitin sulfate inokuthintela ngokufanelekileyo kwaye iphathe isifo senhliziyo.Ine-anti-atherosclerosis kunye nemiphumo yokulwa ne-atherogenic plaque kwiimodeli zovavanyo ze-arteriosclerosis;kwandisa amasebe e-coronary okanye i-collateral circulation ye-atherosclerosis, kwaye inokukhawulezisa uvavanyo lwe-coronary arteriosclerosis okanye i-embolism.Ukuphilisa, ukuvuselelwa kunye nokulungiswa kwe-myocardial necrosis okanye ukuhla.Inokunyusa i-biosynthesis ye-cell messenger ribonucleic acid (mRNA) kunye ne-deoxyribonucleic acid (DNA) kwaye inefuthe lokukhuthaza i-cell metabolism.Umsebenzi ophantsi we-anticoagulant.I-Chondroitin sulfate ine-moderate anticoagulant effect, kwaye nganye i-1 mg ye-chondroitin sulfate A ilingana nomsebenzi we-anticoagulant we-0.45U ye-heparin.Lo msebenzi we-anticoagulant awuxhomekeke kwi-antithrombin III ukuba idlale indima yayo, inokusebenzisa umsebenzi we-anticoagulant ngokusebenzisa inkqubo ye-fibrinogen.I-Chondroitin sulfate nayo ine-anti-inflammatory, ikhawuleza ukuphulukiswa kwesilonda kunye nemiphumo yokuchasana ne-tumor.