I-Paclitaxel 33069-62-4 ye-Anti-tumor ye-Botanical Medicine ye-Ovarian Cancer, i-Breast Cancer

Inkcazo

I-Paclitaxel yi-diterpenoid ye-monomeric ekhutshwe kwi-bark yesityalo sendalo ye-Taxus iyeza.Ukulandelwa kwe-Isotope kubonise ukuba i-paclitaxel ibotshelelwe kuphela kwii-microtubules ze-polymerized kwaye ayizange iphendule ngee-dimers ze-tubulin ezingenayo i-polymerized.Emva kokuba iiseli zibonakaliswe kwi-paclitaxel, inani elikhulu le-microtubules liya kuqokelelwa kwiiseli.Ukuqokelelana kwezi microtubules kuphazamisa imisebenzi eyahlukeneyo yeeseli, ngakumbi ukwahlukana kweeseli kuyeka kwisigaba se-mitotic kwaye kuthintele ukwahlukana okuqhelekileyo kweeseli.Ngophando lwezonyango lwe-Ⅱ-Ⅲ, i-paclitaxel ifaneleka kakhulu umhlaza we-ovarian kunye nomhlaza wamabele, kwaye inefuthe elithile lokunyanga kumhlaza wemiphunga, umhlaza we-colorectal, i-melanoma, umhlaza wentloko kunye nentamo, i-lymphoma kunye nethumba lobuchopho.

Iimpawu

Inefuthe elihle kunyango lomhlaza we-ovarian kunye neplatinam kunye nolunye umhlaza we-ovarian refractory kunye nomhlaza webele.Umhlaza, umhlaza wesisu esingasentla, iiseli ezincinci kunye nomhlaza wemiphunga weseli ongengomncinci unembono entle.

Ukusetyenziswa

Sebenzisa i-1: I-Broad-spectrum anti-tumor botanicals yomhlaza we-ovarian, umhlaza webele, njl.

Sebenzisa i-2: i-broad-spectrum anti-tumor botanicals kunyango lomhlaza we-ovarian, umhlaza webele kunye nezinye izifo.

Sebenzisa i-3: Iziyobisi ze-Antitumor.Kunyango lomhlaza webele we-metastatic kunye nomhlaza we-ovarian we-metastatic.I-Broad-spectrum anti-tumor botanicals kunyango lomhlaza we-ovarian, umhlaza webele kunye nezinye izifo.

Sebenzisa i-4: Ichiza elisebenzayo lokulwa ne-tumor;ibophelela kwingingqi ye-N-terminal ye-β-tubulin, ikhuthaza i-microtubule yangaphambili ezinzile, ixhathisa i-depolymerization, ikhusela ukuhlukana kweeseli eziqhelekileyo kunye nezibatha kwisigaba se-G2 / M somjikelezo weseli.

Sebenzisa i-5: I-anti-microtubule drug, inhibiting depolymerization ngokukhuthaza i-polymerization ye-tubulin, ukugcina ukuzinza kwe-tubulin, kunye nokuvimbela i-cell mitosis.