I-Orlistat 96829-58-2 Ukunciphisa i-Absorption ye-Sietary Fat, okukhokelela ekulahlekeni kobunzima

Iipropati

Umgubo omhlophe wekristale, phantse awunyibiliki emanzini, unyibilika ngokulula kwiklorofomu, unyibilika ngokugqithisileyo kwi-methanol kunye ne-ethanol, kulula ukuyi-pyrolyze, indawo yokunyibilika yi-40℃～42℃. I-molecule yayo yi-diastereomer equkethe amaziko amane e-chiral, kubude be-wavelength ye-529nm, isisombululo sayo se-ethanol sinokujikeleza okungahambi kakuhle.

Indlela yokwenza

I-Orlistat yinto esebenza ixesha elide kunye neyona nto inamandla ye-gastrointestinal lipase inhibitor, eyenza i-enzymes ezimbini ezingentla apha ngokwenza i-covalent bond kunye ne-serine site esebenzayo ye-lipase esiswini kunye namathumbu amancinci. I-enzymes engasebenziyo ayikwazi ukuqhekeza amanqatha ekudleni kwi-fatty acids yamahhala kunye ne-Chemicalbook glycerol enokuthi ifakwe ngumzimba, ngaloo ndlela inciphisa ukutya kunye nokunciphisa ubunzima. Ukongeza, ezinye izifundo zifumene ukuba i-orlistat inqanda ukufunxwa kwamathumbu emathunjini e-cholesterol ngokuthintela i-niemann-pick C1-like protein 1 (niemann-pickC1-like1, NPC1L1).

Iimpawu

Le mveliso ngokudibanisa nokutya okuncinci kwe-hypocaloric kuboniswa kunyango lwexesha elide labantu abatyebileyo nabatyebileyo, kubandakanywa nabo banemingcipheko emiselweyo ehambelana nokukhuluphala. Le mveliso inokulawula ubunzima bexesha elide (ukulahleka kwesisindo, ukugcinwa kwesisindo kunye nokuthintela ukuphindaphinda) ukusebenza kakuhle. Ukuthatha i-orlistat kunokunciphisa imingcipheko enxulumene nokukhuluphala kunye neziganeko zezinye izifo ezinxulumene nokukhuluphala, kubandakanywa ne-hypercholesterolemia, uhlobo lwe-2 yeswekile, ukunyamezela kwe-glucose, i-hyperinsulinemia, i-hypertension, kunye nomxholo we-fat content.

Ukunxibelelana kwezamayeza

Inokunciphisa ukuxutywa kwamavithamini A, D kunye no-E. Inokuxhaswa kunye nale mveliso ngexesha elifanayo. Ukuba uthatha amalungiselelo aqukethe iivithamini A, D kunye ne-E (ezifana nezinye i-multivitamins), kufuneka uthathe le mveliso kwiiyure ezingama-2 emva kokuthatha le mveliso okanye ngexesha lokulala. Abantu abanesifo sikashukela sohlobo lwe-2 banokufuna ukunciphisa umthamo we-oral hypoglycemic agents (umzekelo, i-sulfonylureas). Ukusetyenziswa ngokubambisana kunye ne-cyclosporine kunokubangela ukuhla kwe-plasma concentrations yokugqibela. Ukusetyenziswa kunye ne-amiodarone kunokubangela ukunciphisa ukufunxa kokugqibela kunye nokunciphisa ukusebenza kakuhle.