I-Orlistat 96829-58-2 ukunciphisa ukufunyanwa kwe-fat yamafutha, kukhokelela ekulahlekeni kwesisindo
Iinkcukacha zemveliso
| Igama | I-orlistat |
| Inombolo ye-CAS | I-96829-55-2 |
| Ifomula yemolekyuli | C29h53NO5 |
| Ubunzima bemolekyuli | I-495.73 |
| Inombolo ye-einecs | I-639-755-1 |
| Indawo yokunyibilika | <50 ° C |
| Ukuxinana | I-0.976 ± 0.06G / cm3 (iqikelele) |
| Imeko yokugcina | I-2-8 ° C |
| Ifom | Umgubo |
| Umbala | Mhlophe |
| I-acididity ilunge | (pka) 14.59 ± 0.23 (iqikelele) |
Izithethantonye
. I-ormyl-l-leucne (1s) -1 - [((2s, i-3s) i-Dodecyster; Oxlistat (i-Oxlicat); Orlicat (i-Orlistat)
Isiphumo se-Pharmacociological
Iipropathi
White crystalline powder, almost insoluble in water, easily soluble in chloroform, extremely soluble in methanol and ethanol, easy to pyrolyze, melting point is 40℃～42℃. Imolekyuli yayo i-diastereomer enamaziko amane e-chiral, kwi-Waveethth ye-529n, isisombululo se-ethanol sayo sinomjikelezo ongalunganga.
Imo yesenzo
I-Orlistat yindawo ende enemigangatho ende kwaye enamandla e-gestrointeninal i-Infinitor, ethintela ezi zinto zimbini ze-enzymes ngokwenza i-enzmes ezimbini zendawo esebenzayo yesisu kunye nethumbu. I-enzyment engafakwanga ayinakukophula amanqatha ekutyeni i-acids yasimahla kunye neekhemikhali ze-chemicalcerol enokufakwa emzimbeni, ngaloo ndlela kuncitshiswa ukunciphisa umzimba. Ukongeza, ezinye izifundo zifumanise ukuba i-Orlistit ithintele ukufunxa kwe-cholesterol ngokuthintela i-protein-protein-prothein 1
Iphawu
Le mveliso yokudibanisa kunye ne-Hypocaloric yokutya i-Hypocaloric iboniswe kunyango lwexesha elide lokutyeba nokutyeba kakhulu, kubandakanya nezo zinezinto ezisemngciphekweni ezinxulunyaniswa nokutyeba kakhulu. Le mveliso inolawulo lwexeshana elide (ukunciphisa umzimba, ulondolozo lwesisindo kunye nokuthintela ukusebenza kwakhona) ukusebenza kwakhona. Ukuthatha i-orlistat kunokunciphisa izinto ezinxulumene nobungozi kunye nezinye izifo ezinxulumene nokutyeba kakhulu, kubandakanya i-diabetestemia, uhlobo lwesifo seswekile, i-hlucose, i-hlucose, i-hypertudion, kunye nomxholo wamafutha.
Unxibelelwano lwamayeza
Unokunciphisa ukufunxa kweevithamini A, D kunye E. Inokoxhaswa yile mveliso ngaxeshanye. Ukuba uthatha amalungiselelo aqulathe iivithamini A, D kunye e (ezinjengee-20), kuya kufuneka uthathe le mveliso kwiiyure ezi-2 emva kokuthatha le mveliso okanye ngexesha lokulala. Abantu abanesifo seswekile 2 besifo 2 seswekile banokunciphisa idosi yeearhente ze-hypoglycemic yomlomo (umzekelo, Sulfonylires). Ukulawulwa kwe-Cyclosporine kunokubangela ukwehla kwe-plasma ukugxininiswa kweplasma. Ukusetyenziswa okudibeneyo kwe-Amidionarone kungakhokelela ekunciphiseni kwelokugqibela kwaye kuncitshiswe ukusebenza kakuhle.
