Palopegteriparatide

Palopegteriparatide API

I-Palopegteriparatide yi-hormone receptor agonist yexesha elide ye-parathyroid (PTH1R agonist), ephuhliswe unyango lwe-hypoparathyroidism engapheliyo. I-analog ye-pegylated ye-PTH (1-34) eyenzelwe ukubonelela ngolawulo lwe-calcium oluzinzileyo kunye ne-dosing kanye ngeveki.

Inkqubo kunye noPhando:
I-Palopegteriparatide ibophelela kwi-PTH1 receptors, ibuyisela ibhalansi ye-calcium kunye ne-phosphate ngoku:

• Ukwandisa i-serum calcium

• Ukunciphisa i-urinary calcium excretion

• UkuxhasaI-metabolism yamathambo kunye ne-homeostasis yamaminerali